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Recombinant Human Thymidine Kinase 1, Soluble, His-tagged

Cat.No.: TK1-1342H
Product Overview: Recombinant human TK1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Description: TK1 is an enzyme, a phosphotransferase (a kinase): 2"-deoxythymidine kinase, ATP-thymidine 5"-phosphotransferase. It is present in two forms in mammalian cells, TK1 and TK2. Thymidine kinases have a key function in the synthesis of DNA and thereby in cell division, as they are part of the unique reaction chain to introduce deoxythymidine into the DNA.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT.
Molecular Mass: 28.0 kDa (258aa) confirmed by MALDI-TOF
Protein length: 1-234aa
AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMSCINL PTVLPGSPSK TRGQIQVILG PMFSGKSTEL MRRVRRFQIA QYKCLVIKYA KDTRYSSSFC THDRNTMEAL PACLLRDVAQ EALGVAVIGI DEGQFFPDIV EFCEAMANAG KTVIVAALDG TFQRKPFGAI LNLVPLAESV VKLTAVCMEC FREAAYTKRL GTEKEVEVIG GADKYHSVCR LCYFKKASGQ PAGPDNKENC PVPGKPGEAV AARKLFAPQQ ILQCSPAN
Purity: >90% by SDS - PAGE
Applications: SDS-PAGE
Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -72°C. Avoid repeated freezing and thawing cycles.
Concentration: 1 mg/ml (determined by Bradford assay)
Gene Name: TK1 thymidine kinase 1, soluble [ Homo sapiens ]
Official Symbol: TK1
Synonyms: TK1; thymidine kinase 1, soluble; thymidine kinase, cytosolic; thymidine kinase-1; thymidine kinase 1 soluble isoform; TK2;
Gene ID: 7083
mRNA Refseq: NM_003258
Protein Refseq: NP_003249
MIM: 188300
UniProt ID: P04183
Chromosome Location: 17q23.2-q25.3
Pathway: Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem;
Function: ATP binding; kinase activity; metal ion binding; nucleoside kinase activity; nucleotide binding; thymidine kinase activity; transferase activity; zinc ion binding;

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