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Recombinant Human SIX Homeobox 6, His-tagged

Cat.No. : SIX6-7190H
Product Overview : Recombinant human SIX6 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 30.1kDa.
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  • Gene Information
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Description : SIX6, also as known as OPTX2 and SIX9, belongs to the SIX/Sine oculis homeobox family contains 1 homeobox DNA-binding domain. The SIX homeobox protein is crucial in embryonic development by providing necessary instructions for the formation of the forebrain and eye development. This protein expressed in the developing and adult retina, hypothalamic and the pituitary regions. Defects in SIX6 are the cause of microphthalmia isolated with cataract type 2. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues.
Source : E. coli
Species : Human
Tag : His
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% glycerol, 5mM DTT, 2mM EDTA.
Molecular Mass : 30.1kDa (269aa) confirmed by MALDI-TOF
Protein length : 1-246aa
AA Sequence : MGSSHHHHHH SSGLVPRGSH MGSMFQLPIL NFSPQQVAGV CETLEESGDV ERLGRFLWSL PVAPAACEAL NKNESVLRAR AIVAFHGGNY RELYHILENH KFTKESHAKL QALWLEAHYQ EAEKLRGRPL GPVDKYRVRK KFPLPRTIWD GEQKTHCFKE RTRNLLREWY LQDPYPNPSK KRELAQATGL TPTQVGNWFK NRRQRDRAAA AKNRLQQQVL SQGSGRALRA EGDGTPEVLG VATSPAASLS SKAATSAISI TSSDSECDI
Purity : >90% by SDS - PAGE
Applications : SDS-PAGE
Storage : Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5 mg/ml (determined by Bradford assay)
Gene Name : SIX6 SIX homeobox 6 [ Homo sapiens ]
Official Symbol : SIX6
Synonyms : SIX6; SIX homeobox 6; OPTX2, sine oculis homeobox (Drosophila) homolog 6 , sine oculis homeobox homolog 6 (Drosophila); homeobox protein SIX6; Six9; optic homeobox 2; homeodomain protein OPTX2; sine oculis homeobox homolog 6; OPTX2; MCOPCT2;
Gene ID : 4990
mRNA Refseq : NM_007374
Protein Refseq : NP_031400
MIM : 606326
UniProt ID : O95475
Chromosome Location : 14q23.1
Function : sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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