Recombinant Human Parvin, Alpha, His-tagged

• Cat.No.: PARVA-7196H
• Product Overview: Recombinant human PARVA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 44.6 kDa.

Specification

• Description: Alpha-parvin, also known as PARVA, probably plays a role in the regulation of cell adhesion and cytoskeleton organization. This protein plays a role in ciliogenesis.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT.
• Molecular Mass: 44.6 kDa (395aa) confirmed by MALDI-TOF
• Protein length: 1-372aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMATSPQK SPSVPKSPTP KSPPSRKKDD SFLGKLGGTL ARRKKAKEVS ELQEEGMNAI NLPLSPIPFE LDPEDTMLEE NEVRTMVDPN SRSDPKLQEL MKVLIDWIND VLVGERIIVK DLAEDLYDGQ VLQKLFEKLE SEKLNVAEVT QSEIAQKQKL QTVLEKINET LKLPPRSIKW NVDSVHAKSL VAILHLLVAL SQYFRAPIRL PDHVSIQVVV VQKREGILQS RQIQEEITGN TEALSGRHER DAFDTLFDHA PDKLNVVKKT LITFVNKHLN KLNLEVTELE TQFADGVYLV LLMGLLEGYF VPLHSFFLTP DSFEQKVLNV SFAFELMQDG GLEKPKPRPE DIVNCDLKST LRVLYNLFTK YRNVE
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: PARVA parvin, alpha [ Homo sapiens ]
• Official Symbol: PARVA
• Synonyms: PARVA; parvin, alpha; matrix remodelling associated 2 , MXRA2; alpha-parvin; FLJ10793; FLJ12254; actopaxin; matrix-remodeling-associated protein 2; calponin-like integrin-linked kinase-binding protein; MXRA2; CH-ILKBP; FLJ25106; FLJ46049
• Gene ID: 55742
• mRNA Refseq: NM_018222
• Protein Refseq: NP_060692
• MIM: 608120
• UniProt ID: Q9NVD7
• Chromosome Location: 11p15.3
• Pathway: Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-extracellular matrix interactions, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Localization of the PINCH-ILK-PARVIN complex to focal adhesions, organism-specific biosystem; Regulation of cytoskeletal remodeling and cell spreading by IPP complex components, organism-specific biosystem
• Function: actin binding; protein binding