"CSK" Related Products

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Recombinant Human CSK (Active), GST-tagged

Cat.No.: CSK-1394H
Product Overview: Recombinant full-length human CSK was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Description: CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src through tyrosine phosphorylation of the c-src carboxy terminus. A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells. This association is highly specific and it is speculated that PEP may be an effector and/or regulator of CSK in T cells and other hemopoietic cells.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity: 425 nmol/min/mg
Molecular Mass: ~78 kDa
Protein length: Full length
Purity: >85%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: CSK c-src tyrosine kinase [ Homo sapiens ]
Official Symbol: CSK
Synonyms: CSK; c-src tyrosine kinase; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; MGC117393;
Gene ID: 1445
mRNA Refseq: NM_001127190
Protein Refseq: NP_001120662
MIM: 124095
UniProt ID: P41240
Chromosome Location: 15q24.1
Pathway: Adaptive Immune System, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem; Disease, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem;
Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; proline-rich region binding; protein C-terminus binding; protein binding; protein phosphatase binding; protein tyrosine kinase activity; protein tyrosine phosphatase activity;

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