Active Recombinant Human DMPK, GST-tagged
Cat.No. : | CDC42BPG-1396H |
Product Overview : | Recombinant full-length human DMPK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | DMPK (or Myotonic Dystrophy Protein Kinase) is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. DMPK protein has a leucine-rich domain at the N-terminus, a serine/threonine kinase domain in the middle, and a hydrophobic region at the C-terminus. The N-terminus of DMPK plays an important role in DMPK kinase activity, and the C-terminus of DMPK determines the intracellular localization of the protein. Myotonic dystrophy type 1 is an autosomal dominant disease caused by a trinucleotide repeat-expansion, cytosine-thymine-guanine (CTG)n, in the 3 untranslated region of DMPK. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 4.5 nmol/min/mg |
Molecular Mass : | ~105kDa |
Protein length : | Full length |
Purity : | >90% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) [ Homo sapiens ] |
Official Symbol : | CDC42BPG |
Synonyms : | CDC42BPG; CDC42 binding protein kinase gamma (DMPK-like); serine/threonine-protein kinase MRCK gamma; DMPK2; HSMDPKIN; kappa 200; MRCKgamma; MRCK gamma; DMPK-like gamma; CDC42-binding protein kinase gamma; myotonic dystrophy protein kinase-like alpha; myotonic dystrophy protein kinase-like gamma; myotonic dystrophy protein kinase like protein; myotonic dystrophy kinase-related CDC42-binding kinase gamma; MRCKG; KAPPA-200; |
Gene ID : | 55561 |
mRNA Refseq : | NM_017525 |
Protein Refseq : | NP_059995 |
MIM : | 613991 |
UniProt ID : | Q6DT37 |
Chromosome Location : | 11q13 |
Function : | ATP binding; ATP binding; magnesium ion binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; small GTPase regulator activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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