"HIPK1" Related Products

Recombinant Human HIPK1 (Active), GST-tagged

Cat.No. : HIPK1-1413H
Product Overview : Recombinant human HIPK1 (156-555) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : HIPK1 or homeodomain-interacting protein kinase 1 is a ser/thr protein kinase and a member of the HIPK family. HIPK 1 is a nuclear kinase that phosphorylates homeodomain transcription factors. HIPK1 phosphorylates DAXX and this leads to its relocalization and subsequent decrease in transcriptional repression activity. HIPK1also interacts with p53 and phosphorylates it on serine residues. HIPK 1 expression is elevated in breast cancer cell lines and embryonic fibroblasts from HIPK 1-null mice show more susceptibility to apoptosis induced by DNA damage.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 79 nmol/min/mg
Molecular Mass : ~71 kDa
Protein length : 156-555 aa
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : HIPK1 homeodomain interacting protein kinase 1 [ Homo sapiens ]
Official Symbol : HIPK1
Synonyms : HIPK1; homeodomain interacting protein kinase 1; homeodomain-interacting protein kinase 1; KIAA0630; MGC26642; MGC33446; MGC33548; Myak; Nbak2; nuclear body-associated kinase 2; nuclear body associated kinase 2b; homeodomain interacting protein kinase 1-like protein;
Gene ID : 204851
mRNA Refseq : NM_152696
Protein Refseq : NP_689909
MIM : 608003
UniProt ID : Q86Z02
Chromosome Location : 1p13.1
Function : ATP binding; DNA binding; nucleotide binding; protein binding; protein serine/threonine kinase activity;

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