Active Recombinant Human LATS1, GST-tagged
Cat.No. : | LATS1-1423H |
Product Overview : | Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Description : | LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. |
Source : | Sf9 Cells |
Species : | Human |
Tag : | GST |
Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
Bio-activity : | 1.4 nmol/min/mg |
Molecular Mass : | ~95 kDa |
Protein length : | 589 aa-end |
Purity : | >75% |
Applications : | Kinase Assay, Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.1μg/μl |
Gene Name : | LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) [ Homo sapiens ] |
Official Symbol : | LATS1 |
Synonyms : | LATS1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 1; serine/threonine-protein kinase LATS1; WARTS; h-warts; WARTS protein kinase; large tumor suppressor homolog 1; wts; |
Gene ID : | 9113 |
mRNA Refseq : | NM_004690 |
Protein Refseq : | NP_004681 |
MIM : | 603473 |
UniProt ID : | O95835 |
Chromosome Location : | 6q25.1 |
Pathway : | Signal Transduction, organism-specific biosystem; Signaling by Hippo, organism-specific biosystem; |
Function : | ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; |
Products Types
◆ Recombinant Protein | ||
LATS1-5003M | Recombinant Mouse LATS1 Protein, His (Fc)-Avi-tagged | +Inquiry |
LATS1-2707Z | Recombinant Zebrafish LATS1 | +Inquiry |
LATS1-8971M | Recombinant Mouse LATS1 Protein | +Inquiry |
◆ Lysates | ||
LATS1-974HCL | Recombinant Human LATS1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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