"LATS1" Related Products

Recombinant Human LATS1 (Active), GST-tagged

Cat.No.: LATS1-1423H
Product Overview: Recombinant human LATS1 (589-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 1.4 nmol/min/mg
Molecular Mass: ~95 kDa
Protein length: 589 aa-end
Purity: >75%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) [ Homo sapiens ]
Official Symbol: LATS1
Synonyms: LATS1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 1; serine/threonine-protein kinase LATS1; WARTS; h-warts; WARTS protein kinase; large tumor suppressor homolog 1; wts;
Gene ID: 9113
mRNA Refseq: NM_004690
Protein Refseq: NP_004681
MIM: 603473
UniProt ID: O95835
Chromosome Location: 6q25.1
Pathway: Signal Transduction, organism-specific biosystem; Signaling by Hippo, organism-specific biosystem;
Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase binding; protein serine/threonine kinase activity;

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