"MINK1" Related Products


Recombinant Human MINK1 (Active), GST-tagged

Cat.No. : MINK1-1431H
Product Overview : Recombinant human MINK1 (1-320) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Description : MINK1 is a member of the germinal center family of kinases that are homologous to the Ste20 family and regulate a wide variety of cellular processes, including cell morphology, cytoskeletal rearrangement, and survival. Overexpression of kinase-dead mutants of MINK1 leads to enhanced cell spreading, actin stress fiber formation, adhesion to extracellular matrix and decreased cell motility and invasion. MINK is activated after Ras induction via a mechanism involving reactive oxygen species and mediates stimulation of p38 MAPK downstream of the Raf/ERK pathway.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Bio-activity : 19 nmol/min/mg
Molecular Mass : ~61 kDa
Protein length : 1-320 aa
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : MINK1 misshapen-like kinase 1 [ Homo sapiens ]
Official Symbol : MINK1
Synonyms : MINK1; misshapen-like kinase 1; misshapen like kinase 1 (zebrafish); B55; MAP4K6; MINK; misshapen/NIK related kinase; YSK2; ZC3; MEKKK 6; MEK kinase kinase 6; GCK family kinase MINK; misshapen/NIK-related kinase; MAPK/ERK kinase kinase kinase 6; serine/threonine protein kinase; mitogen-activated protein kinase kinase kinase kinase 6; hMINK; hMINKbeta; MGC21111;
Gene ID : 50488
mRNA Refseq : NM_001024937
Protein Refseq : NP_001020108
MIM : 609426
UniProt ID : Q8N4C8
Chromosome Location : 17p13.2
Pathway : Insulin Signaling, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; small GTPase regulator activity;

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