"PI4K2A" Related Products


Recombinant Human PI4K2A (Active), GST-tagged

Cat.No. : PI4K2A-1450H
Product Overview : Recombinant full-length human PI4K2A was co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : PI4K2A or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4K2A is also required for Wnt to regulate LRP6 phosphorylation.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 95 nmol/min/mg
Molecular Mass : ~79 kDa
Protein length : Full length
Purity : >95%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : PI4K2A phosphatidylinositol 4-kinase type 2 alpha [ Homo sapiens ]
Official Symbol : PI4K2A
Synonyms : PI4K2A; phosphatidylinositol 4-kinase type 2 alpha; phosphatidylinositol 4-kinase type 2-alpha; DKFZP761G1923; PI4KII; PIK42A; phosphatidylinositol 4-kinase type II-alpha; phosphatidylinositol 4-kinase type II (PI4KII); RP11-548K23.6; DKFZp761G1923;
Gene ID : 55361
mRNA Refseq : NM_018425
Protein Refseq : NP_060895
MIM : 609763
UniProt ID : Q9BTU6
Chromosome Location : 10q24
Pathway : 3-phosphoinositide biosynthesis, organism-specific biosystem; 3-phosphoinositide biosynthesis, conserved biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem; D-myo-inositol (1,4,5)-trisphosphate biosynthesis, conserved biosystem; Inositol phosphate metabolism, organism-specific biosystem; Inositol phosphate metabolism, conserved biosystem;
Function : 1-phosphatidylinositol 4-kinase activity; ATP binding; kinase activity; magnesium ion binding; nucleotide binding; transferase activity;

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