"SIK3" Related Products

Recombinant Human SIK3 (Active), GST-tagged

Cat.No.: SIK3-1482H
Product Overview: Recombinant human SIK3 (1-307) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm. Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer. There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer (3). SIK3 is a novel tumor-associated antigen (TAA).
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 140 nmol/min/mg
Molecular Mass: ~62 kDa
Protein length: 1-307 aa
Purity: >90%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1μg/μl
Gene Name: SIK3 SIK family kinase 3 [ Homo sapiens ]
Official Symbol: SIK3
Synonyms: SIK3; SIK family kinase 3; serine/threonine-protein kinase SIK3; FLJ12240; KIAA0999; L19; QSK; salt-inducible kinase 3; serine/threonine-protein kinase QSK; SIK-3;
Gene ID: 23387
mRNA Refseq: NM_025164
Protein Refseq: NP_079440
UniProt ID: Q9Y2K2
Chromosome Location: 11q23.3
Pathway: LKB1 signaling events, organism-specific biosystem;
Function: ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity;

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