Active Recombinant Human SRMS, GST-tagged

• Cat.No.: SRMS-1485H
• Product Overview: Recombinant human SRMS (215-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: SRMS is a Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites that is involved in proliferation or differentiation of keratinocytes in the skin. SRMS functions as a rapid downstream signaling intermediate following calcium-induced differentiation in keratinocytes. SRMS constitutes a new family of non-receptor tyrosine kinases that may be redundant in function. SRMS can act either in the membrane or at the nucleus, and may change localization patterns depending on external stimuli.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 24 nmol/min/mg
• Molecular Mass: ~54 kDa
• Protein length: 215 aa-end
• Purity: >95%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites [ Homo sapiens ]
• Official Symbol: SRMS
• Synonyms: SRMS; src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; C20orf148, chromosome 20 open reading frame 148; tyrosine-protein kinase Srms; dJ697K14.1; SRM; C20orf148
• Gene ID: 6725
• mRNA Refseq: NM_080823
• Protein Refseq: NP_543013
• UniProt ID: Q9H3Y6
• Chromosome Location: 20q13.33
• Pathway: Focal Adhesion, organism-specific biosystem
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding