"TLK1" Related Products

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Recombinant Human TLK1 (Active), GST-tagged

Cat.No. : TLK1-1497H
Product Overview : Recombinant full-length human TLK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 6.2 nmol/min/mg
Molecular Mass : ~135 kDa
Protein length : Full length
Purity : >90%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : TLK1 tousled-like kinase 1 [ Homo sapiens ]
Official Symbol : TLK1
Synonyms : TLK1; tousled-like kinase 1; serine/threonine-protein kinase tousled-like 1; KIAA0137; PKU BETA; SNARE protein kinase SNAK; serine threonine protein kinase; PKU-beta;
Gene ID : 9874
mRNA Refseq : NM_001136554
Protein Refseq : NP_001130026
MIM : 608438
UniProt ID : Q9UKI8
Chromosome Location : 2q31.1
Function : ATP binding; nucleotide binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity;

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