"TNIK" Related Products

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Recombinant Human TNIK (Active), GST-tagged

Cat.No. : TNIK-1499H
Product Overview : Recombinant human TNIK (1-367) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : TNIK or TRAF2 and NCK interacting kinase is characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function. TNIK is mainly expression in brain, heart, and spleen and it is a specific effector of RAP2 which regulate actin cytoskeleton. TNIK is autophosphorylated in a manner dependent upon lys54 in the ATP-binding pocket of its kinase domain and plays a main role in cytoskeleton regulation.
Source : Sf9 Cells
Species : Human
Tag : GST
Form : Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity : 68 nmol/min/mg
Molecular Mass : ~67 kDa
Protein length : 1-367 aa
Purity : >95%
Applications : Kinase Assay, Western Blot
Storage : Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration : 0.1μg/μl
Gene Name : TNIK TRAF2 and NCK interacting kinase [ Homo sapiens ]
Official Symbol : TNIK
Synonyms : TNIK; TRAF2 and NCK interacting kinase; TRAF2 and NCK-interacting protein kinase; KIAA0551;
Gene ID : 23043
mRNA Refseq : NM_001161560
Protein Refseq : NP_001155032
MIM : 610005
UniProt ID : Q9UKE5
Chromosome Location : 3q26.31
Pathway : Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem; TNF receptor signaling pathway, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; small GTPase regulator activity;

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