"CDK6" Related Products

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Recombinant Human CDK6, Unactive, His-tagged

Cat.No.: CDK6-1537H
Product Overview: Recombinant full-length human CDK6 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Description: CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors.The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the phosphorylation and regulation of the activity of tumor suppressor protein Rb. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivities in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.
Source: Sf9 Cells
Species: Human
Tag: His
Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol.
Molecular Mass: ~39 kDa
Protein length: Full length
Purity: >90%
Applications: Kinase Assay, Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.2μg/μl
Gene Name: CDK6 cyclin-dependent kinase 6 [ Homo sapiens ]
Official Symbol: CDK6
Synonyms: CDK6; cyclin-dependent kinase 6; PLSTIRE; cell division protein kinase 6; serine/threonine-protein kinase PLSTIRE; MGC59692;
Gene ID: 1021
mRNA Refseq: NM_001145306
Protein Refseq: NP_001138778
MIM: 603368
UniProt ID: Q00534
Chromosome Location: 7q21-q22
Pathway: B Cell Receptor Signaling Pathway, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem;
Function: ATP binding; cyclin binding; cyclin-dependent protein kinase activity; nucleotide binding; protein binding;

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