"TRDMT1" Related Products


Recombinant Human TRDMT1 , GST-tagged

Cat.No.: TRDMT1-6969H
Product Overview: Recombinant full-length human TRDMT1 (DNMT2) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: TRDMT1 is responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. TRDMT1 also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, TRDMT1 is distinct and highly conserved in its function among various species. The indirect sequence recognition is also a feature of eukaryotic DNA methyltransferases, which may have arisen from a DNMT2-like RNA methyltransferase. DNMT2 is involved in retrotransposon silencing and telomere integrity in somatic cells.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~67 kDa
Protein length: Full length
Purity: >95%
Applications: Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.1 μg/μ
Gene Name: TRDMT1 tRNA aspartic acid methyltransferase 1 [ Homo sapiens ]
Official Symbol: TRDMT1
Synonyms: TRDMT1; tRNA aspartic acid methyltransferase 1; DNA (cytosine 5 ) methyltransferase 2 , DNMT2; tRNA (cytosine(38)-C(5))-methyltransferase; RNMT1; DNA methyltransferase-2; DNA MTase homolog HsaIIP; tRNA (cytosine-5-)-methyltransferase; DNA (cytosine-5)-methyltransferase-like protein 2; DMNT2; DNMT2; PUMET; MHSAIIP;
Gene ID: 1787
mRNA Refseq: NM_004412
Protein Refseq: NP_004403
MIM: 602478
UniProt ID: O14717
Chromosome Location: 10p15.1
Function: DNA (cytosine-5-)-methyltransferase activity; DNA binding; RNA binding; methyltransferase activity; transferase activity;

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