Recombinant Human PRKAR1A, His-tagged
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Cat.No. : | PRKAR1A-7014H |
Product Overview : | Recombinant full-length human PRKAR1A Protein was expressed in Sf9 insect cells using a C-terminal His tag. |
Description : | PRKAR1A or the cAMP-dependent protein kinase regulatory subunit type I alpha, is part of the type 1 PKA holoenzyme. PRKAR1A is found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in PRKAR1A gene cause Carney complex (CNC) and PRKAR1A can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). |
Source : | Sf9 Cells |
Species : | Human |
Tag : | His |
Form : | Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
Molecular Mass : | ~51 kDa |
Protein length : | Full length |
Purity : | >85% |
Applications : | Western Blot |
Storage : | Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles. |
Concentration : | 0.2 μg/μl |
Gene Name : | PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) [ Homo sapiens ] |
Official Symbol : | PRKAR1A |
Synonyms : | PRKAR1A; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); PRKAR1, TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; tissue-specific extinguisher 1; protein kinase A type 1a regulatory subunit; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; MGC17251; DKFZp779L0468; |
Gene ID : | 5573 |
mRNA Refseq : | NM_002734 |
Protein Refseq : | NP_002725 |
MIM : | 188830 |
UniProt ID : | P10644 |
Chromosome Location : | 17q23-q24 |
Pathway : | Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Aquaporin-mediated transport, organism-specific biosystem; Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calmodulin induced events, organism-specific biosystem; |
Function : | cAMP binding; cAMP-dependent protein kinase regulator activity; nucleotide binding; protein binding; ubiquitin protein ligase binding; |
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◆ Lysates
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