Recombinant Human PRKAR1A, His-tagged PRKAR1A-7014H

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Recombinant Human PRKAR1A, His-tagged

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Cat.No. :	PRKAR1A-7014H
Product Overview :	Recombinant full-length human PRKAR1A Protein was expressed in Sf9 insect cells using a C-terminal His tag.
Description :	PRKAR1A or the cAMP-dependent protein kinase regulatory subunit type I alpha, is part of the type 1 PKA holoenzyme. PRKAR1A is found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in PRKAR1A gene cause Carney complex (CNC) and PRKAR1A can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40).
Source :	Sf9 Cells
Species :	Human
Tag :	His
Form :	Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Molecular Mass :	~51 kDa
Protein length :	Full length
Purity :	>85%
Applications :	Western Blot
Storage :	Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration :	0.2 μg/μl

Gene Name :	PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) [ Homo sapiens ]
Official Symbol :	PRKAR1A
Synonyms :	PRKAR1A; protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1); PRKAR1, TSE1; cAMP-dependent protein kinase type I-alpha regulatory subunit; tissue-specific extinguisher 1; protein kinase A type 1a regulatory subunit; cAMP-dependent protein kinase regulatory subunit RIalpha; cAMP-dependent protein kinase type I-alpha regulatory chain; CAR; CNC; CNC1; PKR1; TSE1; ADOHR; PPNAD1; PRKAR1; MGC17251; DKFZp779L0468;
Gene ID :	5573
mRNA Refseq :	NM_002734
Protein Refseq :	NP_002725
MIM :	188830
UniProt ID :	P10644
Chromosome Location :	17q23-q24
Pathway :	Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Aquaporin-mediated transport, organism-specific biosystem; Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calcium Regulation in the Cardiac Cell, organism-specific biosystem; Calmodulin induced events, organism-specific biosystem;
Function :	cAMP binding; cAMP-dependent protein kinase regulator activity; nucleotide binding; protein binding; ubiquitin protein ligase binding;