"UHMK1" Related Products


Recombinant Human UHMK1 , GST-tagged

Cat.No.: UHMK1-7027H
Product Overview: Recombinant full-length human UHMK1 (KIS) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: UHMK1(KIS) or U2AF homology motif (UHM) kinase 1 is a serine/threonine protein kinase that promotes cell cycle progression through G1 phase. UHMK1 phosphorylates the cyclin-dependent kinase inhibitor 1B (p27Kip1) and this results in its export to the nucleus where it undergoes degradation. UHMK1 is a growth factor-dependent nuclear kinase which can regulate cell cycle progression. Elevated levels of UHMK1 protein in leukemia cells has been shown to promote cell cycle progression. UHMK1 has also been shown to function in the adult nervous system where it is highly expressed and the gene has been associated with schizophrenia.
Source: Sf9 Cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Molecular Mass: ~65 kDa
Protein length: Full length
Purity: >70%
Applications: Western Blot
Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
Concentration: 0.05 μg/μl
Gene Name: UHMK1 U2AF homology motif (UHM) kinase 1 [ Homo sapiens ]
Official Symbol: UHMK1
Synonyms: UHMK1; U2AF homology motif (UHM) kinase 1; serine/threonine-protein kinase Kist; KIS; Kist; KIS protein kinase; kinase interacting with leukemia-associated gene (stathmin); KIST; FLJ23015; DKFZp434C1613;
Gene ID: 127933
mRNA Refseq: NM_001184763
Protein Refseq: NP_001171692
MIM: 608849
UniProt ID: Q8TAS1
Chromosome Location: 1q23.1
Function: ATP binding; RNA binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; ribonucleoprotein complex binding; transferase activity;

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