Recombinant Human TBPL1, His-tagged

• Cat.No.: TBPL1-7114H
• Product Overview: Recombinant human TBPL1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: TBPL1, also known as STUD, TLF, TLP and TRF2, belongs to the TBP family. The TATA box-binding protein (TBP) is an essential component of the basal transcriptional machinery. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2mM DTT, 1mM EDTA
• Molecular Mass: 23.3kDa (209aa)
• Protein length: 1-186aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMDADSDV ALDILITNVV CVFRTRCHLN LRKIALEGAN VIYKRDVGKV LMKLRKPRIT ATIWSSGKII CTGATSEEEA KFGARRLARS LQKLGFQVIF TDFKVVNVLA VCNMPFEIRL PEFTKNNRPH ASYEPELHPA VCYRIKSLRA TLQIFSTGSI TVTGPNVKAV ATAVEQIYPF VFESRKEIL
• Purity: >90 % by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml

Gene Information

• Gene Name: TBPL1 TBP-like 1 [ Homo sapiens ]
• Official Symbol: TBPL1
• Synonyms: TBPL1; TBP-like 1; TATA box-binding protein-like protein 1; STUD; TLF; TLP; TRF2; TBP-related protein; TBP-related factor 2; 21-kDA TBP-like protein; second TBP of unique DNA protein; TATA box-binding protein-related factor 2; MGC:8389; MGC:9620
• Gene ID: 9519
• mRNA Refseq: NM_001253676
• Protein Refseq: NP_001240605
• MIM: 605521
• UniProt ID: P62380
• Chromosome Location: 6q22.1-q22.3
• Pathway: Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Epstein-Barr virus infection, organism-specific biosystem; Epstein-Barr virus infection, conserved biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Herpes simplex infection, organism-specific biosystem
• Function: DNA binding; binding; transcription coactivator activity