"CDKN1A" Related Products


Mouse Anti-Human p21/WAF1 Monoclonal Antibody

Cat. No.: CAB-2544MH
Antigen Description: p21WAF1 is a tumor suppressor gene product critical to maintain proper regulatory control of cell division. p21WAF1 inhibits cyclin/cyclin-dependent kinase (cdk) complexes, causing cell cycle arrest by blocking cell division at the S phase. Various mutations of tumor suppressor genes have been associated with different types of cancers. In these cases, somatic gene therapy with wild-type versions of tumor suppressor genes have been contemplated as anti-cancer therapeutic approaches. p21WAF1 contains p53-binding sites in its promoter and expression of p21WAF1 is induced in WI38 fibroblasts with PMA.
Immunogen: This protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human p21 fusion protein.
Clone Number: MARL067.
Host: Mouse.
Reactivity: Human.
Physical State: Liquid (sterile filtered)
Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2.
Preservative: 0.01% (w/v) Sodium Azide.
Concentration: 1.0 mg/mL (by UV absorbance at 280 nm).
Application: ELISA: 1:5,000 - 1:20,000; WB: 1:2000 - 1:10000; IP: 1:100; Other: User Optimized.
Storage: Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
Gene Name: WAF1 cyclin-dependent kinase inhibitor [ Canis lupus familiaris ]
Official Symbol: WAF1
Synonyms: cyclin-dependent kinase inhibitor 1A (p21, Cip1); MDA-6; CIP1; CDK-interaction protein 1; wild-type p53-activated fragment 1; SDI1; cyclin-dependent kinase inhibitor 1; CAP20; melanoma differentiation associated protein 6; CDKN1; OTTHUMP00000016298; P21; DNA synthesis inhibitor; p21Cip1/Waf1; MDA6; p21CIP1; p21; Melanoma differentiation-associated protein 6; PIC1; CDK-interacting protein 1
Gene ID: 403706
mRNA Refseq: AF076469
Protein Refseq: AAC27627
MIM: 116899
UniProt ID: P38936
Chromosome Location: 6p21
Function: proliferation in response to DNA damage; binds to and inhibits cyclin-dependent kinase activity; preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.