Recombinant Human ARL5B, His-tagged
Cat.No. : | ARL5B-3614H |
Product Overview : | Recombinant human ARL5B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
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Cat. No. : | ARL5B-3614H |
Description : | ADP-ribosylation factor-like protein 5B, also known as ARL5B, belongs to a family of proteins that are structurally similar to ADP-ribosylation factors. ARLs and ARFs are part of the RAS superfamily of regulatory GTPases. ARL5B is most closely related to ARL5, with which it shares 80% sequence identity. Human ARL5B shares 100% identity with mouse ARL8 and 71% identity with the Drosophila homolog. Two isoforms of ARL8 exist as a result of alternative splicing events. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT,30% glycerol, 0.1M NaCl, 1mM EDTA |
Molecular Weight : | 22.5 kDa (199aa), confirmed by MALDI-TOF |
Purity : | > 90% by SDS - PAGE |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Sequences of amino acids : | MGSSHHHHHH SSGLVPRGSH MGLIFAKLWS LFCNQEHKVI IVGLDNAGKT TILYQFLMNE VVHTSPTIGS NVEEIVVKNT HFLMWDIGGQESLRSSWNTY YSNTEFIILV VDSIDRERLA ITKEELYRML AHEDLRKAAV LIFANKQDMK GCMTAAEISK YLTLSSIKDH PWHIQSCCAL TGEGLCQGLE WMTSRIGVR |
Storage : | Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | ARL5B ADP-ribosylation factor-like 5B [ Homo sapiens ] |
Official Symbol : | ARL5B |
Synonyms : | ARL5B; ARL8; ADP-ribosylation factor-like protein 5B;OTTHUMP00000019260;ADP-ribosylation factor-like 8;ADP-ribosylation-like factor 8;ADP-ribosylation factor-like protein 8 |
Gene ID : | 221079 |
mRNA Refseq : | NM_178815 |
Protein Refseq : | NP_848930 |
MIM : | 608909 |
UniProt ID : | Q96KC2 |
Chromosome Location : | 10p12.31 |
Function : | GTP binding; nucleotide binding |
Products Types
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ARL5B-26184TH | Recombinant Human ARL5B, His-tagged | +Inquiry |
◆ Lysates | ||
ARL5B-8709HCL | Recombinant Human ARL5B 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionWhile the specific protein interactors of ARL5B are not yet fully elucidated, being a member of the ARL family indicates that it likely interacts with other proteins involved in vesicle trafficking and membrane dynamics within the cell.
Yes, ARL5B protein is evolutionarily conserved across different species, including mammals, suggesting its functional significance in various biological processes.
Currently, there is limited information on post-translational modifications of ARL5B protein. Further research is needed to determine if ARL5B undergoes any modifications, such as phosphorylation or prenylation.
Currently, there are no known therapeutic targets or drugs specifically targeting ARL5B. Further understanding of its function and involvement in diseases is needed to explore its therapeutic potential.
The role of ARL5B in human diseases is currently unclear due to limited research. However, dysregulation of similar proteins involved in vesicle trafficking and membrane dynamics has been associated with various disorders, including neurodegenerative diseases and cancer.
To the best of our knowledge, there are no animal models available specifically targeting ARL5B for studying its function or disease associations. More research is required to develop such models in order to investigate its specific roles.
Limited research has been conducted on the regulation of ARL5B expression. However, some studies suggest that ARL5B expression may be regulated in a tissue-specific manner or in response to specific stimuli. Further investigations are needed to fully understand its regulation.
Customer Reviews (8)
Write a reviewthe manufacturer can play a vital role in supporting and optimizing the research process.
Manufacturers can provide researchers with purified and validated ARL5B protein, ensuring its quality and reliability for use in experiments and trials.
This ensures the consistency and reproducibility of experimental results, promoting confidence in the obtained data.
They can assist in identifying the most suitable experimental protocols or provide recommendations for optimal usage.
This can be particularly important in clinical trials to ensure accurate and reliable results.
The manufacturer can offer technical support and expertise to guide researchers through the experimental process.
Manufacturers may offer the option for custom protein production.
manufacturers offer customization options, such as alternative conjugation methods or tailored formulations, allowing researchers to optimize ARL5B protein to their specific experimental needs.
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