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Recombinant Human CFHR5, His-tagged

Cat.No. : CFHR5-920H
Product Overview : Recombinant Human CFHR5 (Glu19­Glu569) fused with 10­His tag at C terminal, was expressed in Mouse NSO Cells.
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Cat. No. : CFHR5-920H
Description : The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H­like protein 1 and five factor H­ related proteins (FHR­1 to ­5). Members of this family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. The genes of this family have been located in human chromosome 1q32, which is known as the regulator of complement activation (RCA) gene clusters. FHR­5 has been identified initially as a universal component of complement deposits, and detected in glomerular immune deposit. The pattern of deposits is similar to other complement components, suggesting that FHR­5 may play a role in complement activation and regulation. It is synthesized in the liver and consists of 9 SCRs. Its biological function is not understood fully. FHR­5 exhibits similar characteristics as those of factor H in heparin binding, CRP binding, and lipoprotein association. Weak factor I­dependent cofactor activity for C3b cleavage has also been observed.
Source : Mammalian cells
Purity : >90% as determined by SDS-PAGE
PredictedN terminal : Glu 19
MolecularMass : Predicted molecular mass of this protein is 64 KDa. It migrates as an approximately 73 KDa band in SDS-PAGE under reducing conditions.
Formulation : Lyophilized from a 0.2 μm filtered solution in Tris and NaCl.
Endotoxin : <1.0 EU per 1 μg of the protein as determined by the LAL method.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Activity : Measured by its ability to inhibit the binding of biotinylated Recombinant Human Complement Factor H­related 5/CFHR5 to immobilized Recombinant Human C-Reactive Protein/CRP.
Storage : 1 year from date of receipt, ­20 to ­70 °C as supplied. Avoid repeatedFreeze/thaw cycles.
OfficialSymbol : CFHR5
Gene Name : CFHR5 complement factor H-related 5 [ Homo sapiens ]
Synonyms : FHR5; CFHL5; FHR-5; complement factor H-related protein 5; factor H-related protein 5; complement factor H-related 5
Gene ID : 81494
mRNA Refseq : NM_030787
Protein Refseq : NP_110414
MIM : 608593
UniProt ID : Q9BXR6
Chromosome Location : 1q31.3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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