Mouse Anti-C5 Monoclonal Antibody
Cat.No. : | DMABT-H19243 |
Product Overview : | Mouse Anti-C5 Monoclonal Antibody |
- Specification
- Gene Information
- Related Products
Antigen Description : | C5, complement component 5, is a protein involved in the complement system. It is cleaved into C5a and C5b by the C3/C5 convertase. The smaller fragment C5a is an anaphylatoxin and is released into the fluid surroundings. C5a is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis). C5a contains 74 amino acids and is rapidly metabolised by a serum enzyme, carboxypeptidase B to a 73 amino acid form, C5a des-Arg. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. |
Target : | C5 |
Immunogen : | Human C5a |
Host : | Mouse |
Isotype : | IgG1, kappa |
species : | Human |
Conjugation : | Biotin |
Applications : | ELISA,WB,IP |
Preparation : | The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin and unconjugated antibody. |
Usage recommendation : | Each lot of this antibody is quality control tested by ELISA assay. For ELISA detection applications, a concentration range of 0.25-1 μg/ml is recommended. To obtain a linear standard curve, serial dilutions of C5a recombinant protein ranging from 15.6 to 1000 pg/ml are recommended for each ELISA plate. It is recommended that the reagent be titrated for optimal performance for each application. |
Concentration : | 0.5 mg/ml |
Storage : | The antibody solution should be stored undiluted at 4 °C and protected from prolonged exposure to light.Do not freeze. |
Size : | 50 μg;500 μg |
Gene Name : | C5 complement component 5 [ Homo sapiens ] |
Official Symbol : | C5 |
Synonyms : | C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298; |
Gene ID : | 727 |
mRNA Refseq : | NM_001735 |
Protein Refseq : | NP_001726 |
MIM : | 120900 |
UniProt ID : | P01031 |
Chromosome Location : | 9q33-q34 |
Pathway : | Activation of C3 and C5, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; |
Function : | C5a anaphylatoxin chemotactic receptor binding; chemokine activity; endopeptidase inhibitor activity; receptor binding; |
Products Types
◆ Recombinant Protein | ||
C5-348P | Recombinant Pig C5 Protein, His-tagged | +Inquiry |
C5-575H | Recombinant Human C5 Protein (Gln19-Cys1676), His-FLAG-tagged | +Inquiry |
C5-2711M | Recombinant Mouse C5 Protein, His-tagged | +Inquiry |
C5-345H | Recombinant Human C5 Protein, His-tagged | +Inquiry |
C5-347R | Recombinant Rat C5 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
C5-10540H | Active Native Human C5 | +Inquiry |
C5-53H | Native Human Complement C5 | +Inquiry |
◆ Lysates | ||
C5-8020HCL | Recombinant Human C5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, C5 inhibition has shown promise in treating multiple sclerosis by modulating the inflammatory response and reducing damage to the central nervous system.
C5 can be targeted using monoclonal antibodies, such as eculizumab, which inhibits its activity. This approach has been successful in managing various complement-related disorders.
In PNH, a mutation leads to uncontrolled complement activation, resulting in the destruction of red blood cells. Inhibiting C5 can prevent this process and improve clinical outcomes.
C5 inhibition can increase susceptibility to certain infections. Close monitoring and appropriate preventive measures are essential to manage the infection risk in patients receiving C5-targeted therapies.
In rheumatoid arthritis, C5 contributes to inflammation and joint damage. Targeting C5 in treatment may help mitigate the inflammatory response.
Customer Reviews (3)
Write a reviewWhether I am studying protein interactions, cellular localization, or signaling pathways, the C5 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.
Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.
Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.
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