| Species : |
Mouse |
| Source : |
Rat |
| Tag : |
Non |
| Antigen Description : |
Tim-1 is highly expressed by activated CD4+ T cells, and acts as a positive/negative co-stimulatory molecule of T cell proliferation, cytokine production and tolerance abrogation, and is the receptor for Tim-4, expressed on APCs. Tim-1 expression is greater on Th2 than Th1 cells, and studies have shown that interaction between Tim-1 on Th2 cells and Tim-4 on dendritic cells (DCs), enhances Th2 cell function, and have implicated Tim-1 as a critical player in the development of atopic disease, and in particular airway hypersensitivity. |
| specificity : |
It specifically recognises mouse Tim-1 (T-cell immunoglobulin mucin 1), a cell surface glycoprotein and member of the immunoglobulin superfamily, which was first identified as the hepatitis A virus cellular receptor (HAVCR), and is highly expressed in the liver (isoform Tim-1a) and the kidneys (isoform Tim-1b). |
| Target : |
Havcr1 |
| Immunogen : |
Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1. |
| Isotype : |
IgG2a |
| species : |
Mouse |
| Clone : |
RMT1-10 |
| Purification : |
Purified IgG |
| Conjugation : |
N/A |
| Applications : |
ELISA,Flow Cyt,FunS,IFA |
| Dilution : |
Flow Cytometry:1/25 - 1/200 |
| Preparation : |
Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Protein Concentration : |
1.0 mg/ml |
| Storage : |
Store at -20°C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| Shelf life : |
18 months from date of despatch. |
| Size : |
0.5 mg |
