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Recombinant Human Activin A Receptor, Type IIB, His-tagged

Cat.No. : ACVR2B-938H
Product Overview : ACVR2B contains C-terminal polyhistidine tag and has a calculated MW of 41 kDa. DTT-reduced protein migrates as 60 kDa polypeptide in SDS-PAGE.
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Cat. No. : ACVR2B-938H
Description : ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity.
Source : Recombinant human ACVR2B (rhACVR2B) Ser19-Thr134 (Accession CAA54671) was produced in human HEK293 cells.
Species : Human
Form : Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
Purity : >97% as determined by SDS-PAGE. All lots are greater than 97% pure.
Endotoxin : Less than 1.0 EU per 1 μg of the rhACVR2B by the LAL method.
Storage : Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles.
Gene Name : ACVR2B activin A receptor, type IIB [ Homo sapiens ]
Official Symbol : ACVR2B
Synonyms : ACVR2B; activin A receptor, type IIB; ACTRIIB; ActR-IIB; MGC116908; EC 2.7.11.30; Activin receptor type-2B; ACTR-IIB; HTX4; OTTHUMP00000161965
Gene ID : 93
mRNA Refseq : NM_001106
Protein Refseq : NP_001097
MIM : 602730
UniProt ID : Q13705
Chromosome Location : 3p22
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP
Function : ATP binding; activin binding; activin receptor activity, type II; growth factor binding; manganese ion binding; nucleotide binding; protein serine/threonine/tyrosine kinase activity; transferase activity; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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