"BMPR1A" Related Products

Recombinant Human Bone Morphogenetic Protein Receptor, Type IA, His-tagged

Cat. No. : BMPR1A-889H
Product Overview : A DNA sequence encoding the extracellular domain ( Met 1 - Arg 152 ) of human ALK3 ( NP_004320.2 ) was fused with a polyhistidine tag at the C-terminus.
Description : ALK3 is a type I receptor for bone morphogenetic proteins (BMPs). The BMP receptors form a subfamily of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. Type I and II BMP receptors are both indispensable for signal transduction. Upon ligand binding, they form a heterotetrameric-activated receptor complex consisting of two pairs of a type I and a II receptor. Type II receptors can bind ligands in the absence of type I receptors, whereas the respective type I receptors are required for signal transduction.
Source : Human
Host : Human Cells
Form : Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Purity : > 85 % as determined by SDS-PAGE
Endotoxin : ﹤1.0 EU per μg protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70 °C
Predicted N terminal : Gln 24
Molecular Mass : The secreted recombinant human ALK3 consists of 141 amino acids and has a predicted molecular mass of 15.7 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhALK3 is approximately 28-33 kDa due to glycosylation.
Storage : Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
PDB rendering basedon 1es7. :

Gene Name : BMPR1A bone morphogenetic protein receptor, type IA [ Homo sapiens ]
Official Symbol : BMPR1A
Synonyms : BMPR1A; bone morphogenetic protein receptor, type IA; ALK3; SKR5; CD292; ACVRLK3; 10q23del; OTTHUMP00000020014; activin A receptor, type II-like kinase 3; serine/threonine-protein kinase receptor; Bone morphogenetic protein receptor type-1A; EC; Serine/threonine-protein kinase receptor R5; Activin receptor-like kinase 3; ALK-3
Gene ID : 657
mRNA Refseq : NM_004329
Protein Refseq : NP_004320
MIM : 601299
UniProt ID : P36894
Chromosome Location : 10q22.3
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway; Signaling by BMP
Function : ATP binding; SMAD binding; magnesium ion binding; nucleotide binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor activity; transferase activity; transforming growth factor beta receptor activity

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