Active Recombinant Human Fas (TNF receptor superfamily, member 6)

• Cat.No.: CSF3R-3815H
• Product Overview: A DNA sequence encoding the extracellular domain (Met 1-Pro 621) of human CSF3R (NP_000751.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.

Specification

• Cat. No.: CSF3R-3815H
• Description: CSF3R which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3, a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage.
• Source: Human
• Host: Human Cells
• Form: Lyophilized from sterile PBS, pH 7.4, Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
• Purity: > 95 % as determined by SDS-PAGE
• Bio-activity: Measured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells. The ED50 for this effect is typically 1-4 ng/ml in the presence of 0.125 ng/mL of recombinant human GCSF.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70°C.
• Predicted N terminal: Glu 25
• Molecular Mass: The mature recombinant human CSF3R is a disulfide-linked homodimeric protein. The reduced monomer consists of 835 amino acids and predicts a molecular mass of 93.3 KDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rh CSF3R monomer is approximately 120-130 KDa due to glycosylation.
• Storage: Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens ]
• Official Symbol: CSF3R
• Synonyms: CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; GCSFR; granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor; OTTHUMP00000009703; OTTHUMP00000009704; OTTHUMP00000009705
• Gene ID: 1441
• mRNA Refseq: NM_000760
• Protein Refseq: NP_000751
• MIM: 138971
• UniProt ID: Q99062
• Chromosome Location: 1p35-p34
• Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Pathways in cancer
• Function: cytokine receptor activity; receptor activity