Recombinant Human Fas (TNF receptor superfamily, member 6) CSF3R-3815H

Recombinant Human Fas (TNF receptor superfamily, member 6)

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Recombinant Human Fas (TNF receptor superfamily, member 6)

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Cat. No. : CSF3R-3815H
Product Overview : A DNA sequence encoding the extracellular domain (Met 1-Pro 621) of human CSF3R (NP_000751.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
Description : CSF3R which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3, a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage.
Source : Human
Host : Human Cells
Form : Lyophilized from sterile PBS, pH 7.4, Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Purity : > 95 % as determined by SDS-PAGE
Bio-activity : Measured by its ability to inhibit the GCSF-induced proliferation of NFS-60 mouse myeloid cells. The ED50 for this effect is typically 1-4 ng/ml in the presence of 0.125 ng/mL of recombinant human GCSF.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70°C.
Predicted N terminal : Glu 25
Molecular Mass : The mature recombinant human CSF3R is a disulfide-linked homodimeric protein. The reduced monomer consists of 835 amino acids and predicts a molecular mass of 93.3 KDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rh CSF3R monomer is approximately 120-130 KDa due to glycosylation.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
PDB rendering basedon 2d9q :

Gene Name : CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens ]
Official Symbol : CSF3R
Synonyms : CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; GCSFR; granulocyte colony-stimulating factor receptor; G-CSF-R; CD114 antigen; G-CSF receptor; OTTHUMP00000009703; OTTHUMP00000009704; OTTHUMP00000009705
Gene ID : 1441
mRNA Refseq : NM_000760
Protein Refseq : NP_000751
MIM : 138971
UniProt ID : Q99062
Chromosome Location : 1p35-p34
Pathway : Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway; Pathways in cancer
Function : cytokine receptor activity; receptor activity

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