Recombinant Human Fas (TNF receptor superfamily, member 6)
Cat.No. : | FAS-3814H |
Product Overview : | A DNA sequence encoding the extracellular domain (Met 1-Glu 173) of human Fas antigen (NP_000034.1) was fused with the Fc region of human IgG1 at the C-terminus. |
- Specification
- Gene Information
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Cat. No. : | FAS-3814H |
Description : | FAS is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily. FAS is highly expressed on the surface of a number of cell types including epithelial cells, hepatocytes, activated mature lymphocytes and other tumor cells. This receptor contains a death domain and has been shown to play a central role in the physiological regulation of programmed cell death (PCD, apoptosis) upon ligation of Fas ligand (Fas-L). |
Source : | Human |
Host : | Human Cells |
Form : | Lyophilized from sterile PBS, pH 7.4, Normally 5%-8% trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. |
Purity : | > 95 % as determined by SDS-PAGE |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Stability : | Samples are stable for up to twelve months from date of receipt at -70°C. |
Predicted N terminal : | Gln 26 |
Molecular Mass : | The recombinant human FAS chimera is a disulfide-linked homodimeric protein generated after removal of the signal peptide. The reduced monomer consists of 386 amino acids and has a predicted molecular mass of 43.4 kDa. In SDS-PAGE under reducing conditions, the monomer migrates as an approximately 55-60 kDa protein due to glycosylation. |
Storage : | Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Gene Name : | FAS Fas (TNF receptor superfamily, member 6) [ Homo sapiens ] |
Official Symbol : | FAS |
Synonyms : | FAS; Fas (TNF receptor superfamily, member 6); APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; tumor necrosis factor receptor superfamily member 6; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor; OTTHUMP00000020045; OTTHUMP00000020046; OTTHUMP00000020051; OTTHUMP00000217569; apoptosis antigen 1; APO-1 cell surface antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6 |
Gene ID : | 355 |
mRNA Refseq : | NM_000043 |
Protein Refseq : | NP_000034 |
MIM : | 134637 |
UniProt ID : | P25445 |
Chromosome Location : | 10q24 |
Pathway : | Adipogenesis; African trypanosomiasis; Alzheimer"s disease; Apoptosis; Autoimmune thyroid disease; Death Receptor Signalling; Direct p53 effectors; FasL/CD95L signaling; Influenza A; MAPK signaling pathway; Measles; Natural killer cell mediated cytotoxicity; Pathways in cancer; Type I diabetes mellitus; p53 signaling pathway |
Function : | binding; kinase binding; protein binding; receptor activity; signal transducer activity; transmembrane signaling receptor activity; tumor necrosis factor receptor activity |
Products Types
◆ Recombinant Protein | ||
Fas-12R | Recombinant Rat Fas Protein, His (Fc)-Avi-tagged | +Inquiry |
Fas-1020M | Recombinant Mouse Fas Protein, MYC/DDK-tagged | +Inquiry |
FAS-258C | Recombinant Cynomolgus Monkey FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
FAS-3853H | Recombinant Human FAS Protein, GST-tagged | +Inquiry |
FAS-1468R | Recombinant Rhesus Macaque FAS Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FAS-001CCL | Recombinant Cynomolgus FAS cell lysate | +Inquiry |
FAS-1139RCL | Recombinant Rat FAS cell lysate | +Inquiry |
FAS-2419MCL | Recombinant Mouse FAS cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionFAS protein plays an important role in cell signaling, it can activate downstream signaling pathways, such as death signaling pathway and survival signaling pathway, by binding to its ligand and transmitting signals.
It can provide a reference for clinical practice and guide the diagnosis, treatment and prevention of diseases by detecting the expression level of FAS protein and understanding its mechanism of action.
FAS protein-related diseases can be prevented and treated by regulating the expression level of FAS protein and inhibiting its signaling pathway.
Gene knockout or knockdown techniques can be used to study the function and mechanism of action of FAS proteins. By knocking out or knocking down the FAS gene, changes in processes such as apoptosis and immune response can be observed to further understand its function and mechanism of action.
FAS protein can bind to its ligand, activate the death signaling pathway, and induce apoptosis.
The expression level and activity of FAS protein can be measured to predict the prognosis and development trend of certain diseases.
Customer Reviews (3)
Write a reviewWhen experimenting with FAS, the results are very reproducible.
The stability of FAS products allows them to cope with different experimental conditions and modes of operation.
FAS has high specific activity and can exert strong biological effect at low concentration.
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