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Recombinant Human Glucagon

Cat. No. : GCG-295H
Product Overview : Glucagon Like Peptide-2 contains 34 amino acids having a molecular mass of 3922.38 Dalton.
Description : GLP-2 functions as an intestinal growth factor, which stimulates intestinal epithelial growth. GLP2 is involved in diabetes-associated bowel growth. GLP2 enhances cell differentiation, playing a role as a cytokine and in tissue regeneration, and mediating cytoprotection. GLP2 is invloded numerous therapeutic applications. GLP2 regulates signaling pathways coupled to cell proliferation and cell death by apoptosis. GLP-2 is produced by specific post-translational proteolytic cleavage of proglucagon GLP-2 is manufactured by the intestinal endocrine L cell and by several neurons in the central nervous system.
Source : Human
Form : The protein (1mg/ml) was lyophilized with no additives.
Purity : Greater than 95.0% as determined by RP-HPLC.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized GLP-2 in sterile 18Mμ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence : His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala- Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-Arg.
Storage : Lyophilized GLP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution GLP2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Pathways : Neuroactive ligand-receptor interaction; Diabetes pathways; Integration of energy metabolism; Signaling by GPCR
PDBrendering based on 1d0r. :

Gene Name : GCG glucagon [ Homo sapiens ]
Official Symbol : GCG
Synonyms : GCG; glucagon; GLP1; GLP2; GRPP; glucagon-like peptide 1; glucagon-like peptide 2; glicentin-related polypeptide
Gene ID : 2641
mRNA Refseq : NM_002054
Protein Refseq : NP_002045
MIM : 138030
UniProt ID : P01275
Chromosome Location : 2q36-q37
Function : hormone activity

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