Recombinant Human Histidine Triad Nucleotide Binding Protein 1

• Cat.No.: HINT1-4397H
• Product Overview: HINT1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 126 amino acids (1-126 a.a.) and having a molecular mass of 13.8 kDa. The HINT1 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: HINT1-4397H
• Description: HINT1, also known as Histidine triad nucleotide-binding protein 1 is part of the superfamily named for a near C-terminal HXHXHXX motif (H:Histidine, X:a hydrophobic amino acid) positioned at the ?-phosphate of nucleotide substrates. HINT1 hydrolyzes adenosine 5"-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2. Though it was initially considered to be a protein kinase C inhibitor and act as a haplod-insufficient tumor suppressor including spontaneous tumor formation in Hint+/- and Hint-/- , its actual physiologic function is not known.
• Source: Human
• Host: Escherichia Coli.
• Form: The HINT1 solution contains 20mM Tris pH-8 & 10% glycerol.
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Physical Appearance: Sterile Filtered colorless solution.
• Amino acid sequence: MADEIAKAQV ARPGGDTIFG KIIRKEIPAK IIFEDDRCLA FHDISPQAPT HFLVIPKKHI SQISVAEDDD ESLLGHLMIV GKKCAADLGL NKGYRMVVNE GSDGGQSVYH VHLHVLGGRQ MHWPPG.
• Storage: HINT1 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: HINT1 histidine triad nucleotide binding protein 1 [ Homo sapiens ]
• Official Symbol: HINT1
• Synonyms: HINT1; histidine triad nucleotide binding protein 1; HINT; PKCI-1; PRKCNH1; FLJ30414; FLJ32340; histidine triad nucleotide-binding protein 1; OTTHUMP00000159244; protein kinase C inhibitor 1; adenosine 5"-monophosphoramidase; protein kinase C-interacting protein 1; Adenosine 5"-monophosphoramidase; EC 3.-.-.
• Gene ID: 3094
• mRNA Refseq: NM_005340
• Protein Refseq: NP_005331
• MIM: 601314
• UniProt ID: P49773
• Chromosome Location: 5q31.2
• Function: hydrolase activity; protein kinase C binding