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Recombinant Human Hemopexin

Cat.No. : HPX-4391H
Product Overview : Human Hemopexin produced in Human plasma having a molecular mass of 70 kDa.
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Cat. No. : HPX-4391H
Description : HPX (or haemopexin) is a plasma protein that binds heme with the highest affinity of any known protein. HPX is generally expressed in liver, and belongs to acute phase reactants, the synthesis of which is induced after inflammation. Heme is potentially very toxic because of its ability to intercalate into lipid membrane and to generate hydroxyl radicals. HPXμs function of scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin defends the body from the oxidative damage that free heme can cause. Additionally, HPX discharges its bound ligand for internalisation upon interacting with a specific receptor located on the surface of liver cells. This HPX function is in order to preserve the body"s iron. HPXμs levels in the serum are an indication of how much heme is present in the blood. Low HPX levels show that there is a lot of it in the serum. For that reason, low HPX levels indicate that there has been considerable degradation of heme containing compounds - mainly hemoglobin, it indicates hemolysis and low HPX levels are therefore one of the diagnostic features of a hemolytic anemia. Itμs a Haem binding protein used in the assessment of intravascular haemolysis in conjunction with haptoglobin.
Source : Human
Host : Human Plasma.
Form : Lyophilised from 11.9mM phosphate buffer pH- 7.4, 137mM NaI and 2.7mM KCl.
Purity : Greater than 95.0%.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to reconstitute the lyophilized HPX in phosphate buffer, pH >7.0 containing 0.15M NaCl.
Storage : Human HPX although stable at room temperature for 2 weeks, should be stored at -20°C.
Gene Name : HPX hemopexin [ Homo sapiens ]
Official Symbol : HPX
Synonyms : HPX; hemopexin; HX; beta-1B-glycoprotein; EC 3.2.1.35; FLJ56652; Beta-1B-glycoprotein
Gene ID : 3263
mRNA Refseq : NM_000613
Protein Refseq : NP_000604
MIM : 142290
UniProt ID : P02790
Chromosome Location : 11p15.5-p15.4
Function : binding; heme transporter activity; iron ion binding; metal ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can HPX be used as a diagnostic marker for hemolytic disorders? 03/08/2022

Yes, low levels of HPX in the blood can be an indicator of hemolytic disorders.

How is HPX involved in managing heme in the body? 10/27/2021

HPX binds to free heme released from hemoglobin, preventing its toxic effects and aiding in its clearance.

How does HPX contribute to the prevention of heme-related toxicity? 04/07/2021

HPX binds to heme, preventing its oxidative and inflammatory damage to tissues and organs.

What clinical conditions are associated with heme release, making HPX relevant? 06/10/2018

Hemolysis, hemoglobinopathies, and various types of anemias can lead to heme release, highlighting the clinical relevance of HPX.

How is HPX regulated in the body, and can its levels be influenced by medications? 12/16/2017

HPX levels can be influenced by various factors, including inflammation and medications like glucocorticoids.

Customer Reviews (3)

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Reviews
12/09/2019

    the manufacturer offers a wide range of HPX protein variants, including recombinant or native forms, as well as different conjugates and modifications.

    02/02/2018

      As a researcher using HPX protein, I have found numerous advantages in its application during trials for various experimental purposes.

      08/15/2017

        the HPX protein is known for its strong affinity for phospholipids, particularly phosphatidylserine (PS), on the outer leaflet of cell membranes.

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