Recombinant Human Hemopexin
Cat.No. : | HPX-4391H |
Product Overview : | Human Hemopexin produced in Human plasma having a molecular mass of 70 kDa. |
- Specification
- Gene Information
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Cat. No. : | HPX-4391H |
Description : | HPX (or haemopexin) is a plasma protein that binds heme with the highest affinity of any known protein. HPX is generally expressed in liver, and belongs to acute phase reactants, the synthesis of which is induced after inflammation. Heme is potentially very toxic because of its ability to intercalate into lipid membrane and to generate hydroxyl radicals. HPXμs function of scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin defends the body from the oxidative damage that free heme can cause. Additionally, HPX discharges its bound ligand for internalisation upon interacting with a specific receptor located on the surface of liver cells. This HPX function is in order to preserve the body"s iron. HPXμs levels in the serum are an indication of how much heme is present in the blood. Low HPX levels show that there is a lot of it in the serum. For that reason, low HPX levels indicate that there has been considerable degradation of heme containing compounds - mainly hemoglobin, it indicates hemolysis and low HPX levels are therefore one of the diagnostic features of a hemolytic anemia. Itμs a Haem binding protein used in the assessment of intravascular haemolysis in conjunction with haptoglobin. |
Source : | Human |
Host : | Human Plasma. |
Form : | Lyophilised from 11.9mM phosphate buffer pH- 7.4, 137mM NaI and 2.7mM KCl. |
Purity : | Greater than 95.0%. |
Physical Appearance : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Solubility : | It is recommended to reconstitute the lyophilized HPX in phosphate buffer, pH >7.0 containing 0.15M NaCl. |
Storage : | Human HPX although stable at room temperature for 2 weeks, should be stored at -20°C. |
Gene Name : | HPX hemopexin [ Homo sapiens ] |
Official Symbol : | HPX |
Synonyms : | HPX; hemopexin; HX; beta-1B-glycoprotein; EC 3.2.1.35; FLJ56652; Beta-1B-glycoprotein |
Gene ID : | 3263 |
mRNA Refseq : | NM_000613 |
Protein Refseq : | NP_000604 |
MIM : | 142290 |
UniProt ID : | P02790 |
Chromosome Location : | 11p15.5-p15.4 |
Function : | binding; heme transporter activity; iron ion binding; metal ion binding |
Products Types
◆ Recombinant Protein | ||
HPX-1889H | Recombinant Human HPX Protein, MYC/DDK-tagged | +Inquiry |
HPX-3122H | Recombinant Human HPX Protein, His (Fc)-Avi-tagged | +Inquiry |
HPX-2563R | Recombinant Rat HPX Protein, His (Fc)-Avi-tagged | +Inquiry |
HPX-5021H | Recombinant Human HPX Protein, GST-tagged | +Inquiry |
Hpx-1167M | Recombinant Mouse Hpx Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
HPX-29307TH | Native Human HPX | +Inquiry |
HPX-206H | Native Human Native Human HPX | +Inquiry |
HPX-207H | Native Human Hemopexin | +Inquiry |
◆ Lysates | ||
HPX-2789HCL | Recombinant Human HPX cell lysate | +Inquiry |
HPX-2279MCL | Recombinant Mouse HPX cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, low levels of HPX in the blood can be an indicator of hemolytic disorders.
HPX binds to free heme released from hemoglobin, preventing its toxic effects and aiding in its clearance.
HPX binds to heme, preventing its oxidative and inflammatory damage to tissues and organs.
Hemolysis, hemoglobinopathies, and various types of anemias can lead to heme release, highlighting the clinical relevance of HPX.
HPX levels can be influenced by various factors, including inflammation and medications like glucocorticoids.
Customer Reviews (3)
Write a reviewthe manufacturer offers a wide range of HPX protein variants, including recombinant or native forms, as well as different conjugates and modifications.
As a researcher using HPX protein, I have found numerous advantages in its application during trials for various experimental purposes.
the HPX protein is known for its strong affinity for phospholipids, particularly phosphatidylserine (PS), on the outer leaflet of cell membranes.
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