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Recombinant Human IL7 (26-177aa), Met tagged

Cat. No.: IL7-032E
Product Overview: Recombinant Human IL7 (Asp26 ­ His177, with an N­terminal Met) was expressed in E. coli and produced using non­animal reagent in an animal­free laboratory.
Description: IL­7, previously known as pre­B­cell growth factor and lymphopoietin­1, was originally purified on the basis of its ability to promote the proliferation of precursor B­cells. It has now been shown that IL­7 can also stimulate the proliferation of thymocytes, T cell progenitors and mature CD4+ and CD8+ T cells. IL­7 can induce the formation of lymphokine­activated killer (LAK) cells as well as the development of cytotoxic T lymphocytes (CTL). IL­7 was also shown to induce the V(D)J rearrangement of the T cell receptor μ gene in mouse fetal thymocytes. Among myeloid lineage cells, IL ­7 can up­regulate the production of pro­inflammatory cytokines and stimulate the tumoricidal activity of monocytes/macrophages. IL­7 is expressed by adherent stromal cells from various tissues.
Source: E. coli
N­terminal Sequence Analysi: Met
Molecular Mass: 17 kDa
Activity: Measured in a cell proliferation assay using PHA­activated human peripheral blood lymphocytes. The ED50 for this effect is typically 0.2 ­ 0.5 ng/mL.
Endotoxin Leve: <1.0 EU per 1 μg of the protein by the LAL method.
Purity: >97%, by SDS­PAGE under reducing conditions and visualized by silver stain.
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details.
Reconstitution: Reconstitute at 200 μg/mL in sterile PBS.
Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage: Use a manual defrost freezer and avoid repeated freeze­thaw cycles. 1. 12 months from date of receipt, ­20 to ­70 °C as supplied. 2. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3. 3 months, ­20 to ­70 °C under sterile conditions after reconstitution.
Unitprot ID: P13232
Gene Name: IL7 interleukin 7 [ Homo sapiens ]
Official Symbol: IL7
Synonyms: IL7; interleukin 7; interleukin-7; IL-7
Gene ID: 3574
mRNA Refseq: NM_000880
Protein Refseq: NP_000871
MIM: 146660
Chromosome Location: 8q12-q13
Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Hematopoietic cell lineage; Jak-STAT signaling pathway
Function: cytokine activity; growth factor activity; cytokine receptor binding; interleukin-7 receptor binding; protein binding

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