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Recombinant Chicken Malate Dehydrogenase 1, NAD (Soluble)

Cat. No.: MDH1-1374C
Product Overview: The DNA encoding Malate (Malic) Dehydrogenase is cloned from cDNA library of chicken heart. The MDH1 is purified by proprietary chromatographic techniques.
Description: Malate dehydrogenase (EC1.1.1.37) is an enzyme in the citric acid cycle that catalyzes the conversion of malate into oxaloacetate (using NAD+) and vice versa (this is a reversible reaction). Malate dehydrogenase is not to be confused with malic enzyme, which catalyzes the conversion of pyruvate using NADPH. Malate dehydrogenase is also involved in gluconeogenesis, the synthesis of glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by pyruvate carboxylase to form oxaloacetate, a citric acid cycle intermediate. In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase. Finally, phosphoenol-pyruvate carboxy kinase (PEPCK) converts oxaloacetate to phosphoenol pyruvate.
Source: Chicken
Host: Escherichia Coli.
Form: Each mg of protein contains 0.59mg NaPO4.
Purity: Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Physical Appearance: Sterile lyophilized powder.
Solubility: It is recommended to reconstitute the lyophilized Malate dehydrogenase in sterile 18Mμ-cm H2O.
Storage: Lyophilized Malate dehydrogenase although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MDH1 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.
Gene Name: MDH1 malate dehydrogenase 1, NAD (soluble) [ Homo sapiens ]
Official Symbol: MDH1
Synonyms: MDH1; malate dehydrogenase 1, NAD (soluble); OTTHUMP00000202070; cytosolic malate dehydrogenase; malate dehydrogenase, cytoplasmic; soluble malate dehydrogenase; MDHA; MOR2; MDH-s; MGC: 1375; EC 1.1.1.37
Gene ID: 4190
mRNA Refseq: NM_005917
Protein Refseq: NP_005908
MIM: 154200
UniProt ID: P40925
Chromosome Location: 2p13.3
Function: L-malate dehydrogenase activity; NAD or NADH binding; malic enzyme activity; oxidoreductase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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