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Recombinant Mouse Reticulon 4 Receptor, His-tagged

Cat. No.: Rtn4r-4010M
Product Overview: A DNA sequence encoding the mature form of mouse RTN4R (NP_075358.1) (Met 1-Ser 447) was expressed, fused with a polyhistidine tag at the C-terminus.
Description: Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 10 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult CNS. It has been shown that RTN4R performs its inhibitory actions by interacting with the p75 neurotrophin receptor (p75NTR), a TNFRSF member also known for modulating the activities of the Trk family and for inducing apoptosis in neurons and oligodendrocytes. RTN4R may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer"s disease (AD). Additionally, RTN4R may play a role in regulating the function of the gap junctions.
Source: Mouse
Host: Human Cells
Form: Lyophilized from sterile PBS, pH7.4
Purity: >97 % as determined by SDS-PAGE.
Endotoxin: < 1.0 EU per 1μg of the protein as determined by the LAL method.
Stability: Samples are stable for up to twelve months from date of receipt at -70μ
Predicted N terminal: Cys 27
Molecular Mass: The secreted mature form of mouse RTN4R consists of 432 amino acids and has a predicted molecular mass of 47 kDa. Due to glycosylation, rmRTN4R migrates as an approximately 65 kDa band in SDS-PAGE under reducing conditions.
Storage: Store it under sterile conditions at -70μ. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Gene Name: Rtn4r reticulon 4 receptor [ Mus musculus ]
Official Symbol: Rtn4r
Synonyms: Rtn4r; reticulon 4 receptor; NgR; NOGOR; reticulon-4 receptor; nogo receptor; Nogo-66 receptor
Gene ID: 65079
mRNA Refseq: NM_022982
Protein Refseq: NP_075358
UniProt ID: Q99PI8
Chromosome Location: 16 B1
Function: protein binding; receptor activity

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