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Recombinant Human SerpinB1 protein, His-tagged

Cat.No. : SerpinB1-3981H
Product Overview : Recombinant Human SerpinB1 protein(P30740)(Met1-Pro379), fused with His tag, was expressed in Insect Cells.
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Source : Insect Cells
Species : Human
Tag : His
Form : Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human SERPINB1 consists of 390 amino acids and migrates as an approximately 44 kDa band as predicted in SDS-PAGE under reducing conditions.
Protein Length : Met1-Pro379
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method
Purity : > 90 % as determined by SDS-PAGE
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Publication :
NSP4, an elastase-related protease in human neutrophils with arginine specificity. (2012)
Gene Name : SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 [ Homo sapiens ]
Official Symbol : SerpinB1
Synonyms : SERPINB1; serpin peptidase inhibitor, clade B (ovalbumin), member 1; ELANH2, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1; leukocyte elastase inhibitor; anti elastase; EI; PI2; PI-2; serpin B1; anti-elastase; peptidase inhibitor 2; monocyte/neutrophil elastase inhibitor; protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1; LEI; MNEI; M/NEI; ELANH2;
Gene ID : 1992
mRNA Refseq : NM_030666
Protein Refseq : NP_109591
MIM : 130135
UniProt ID : P30740

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does SERPINB1 contribute to the regulation of protease activity? 02/26/2021

It inhibits neutrophil elastase and cathepsin G, balancing proteolysis.

What are the molecular mechanisms regulating SERPINB1 expression and activity? 08/05/2020

Its expression and activity are regulated by various signaling pathways and transcription factors.

Are there therapeutic applications targeting SERPINB1? 07/01/2020

Potential therapeutic applications could involve modulating SERPINB1 to mitigate damage in inflammatory and infectious diseases.

What role does SERPINB1 play in inflammatory responses? 12/21/2019

It helps control inflammation by modulating protease activity in immune responses.

What is the main function of SERPINB1 in cellular processes? 12/17/2018

SERPINB1 functions as a serine protease inhibitor, regulating protease activity.

How is SERPINB1 implicated in diseases related to inflammation and infection? 07/27/2018

SERPINB1 protects tissues from damage during inflammation and infection.

In which cells or tissues is SERPINB1 predominantly expressed? 05/13/2018

SERPINB1 is predominantly expressed in neutrophils and some other immune cells.

Customer Reviews (3)

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Reviews
06/14/2022

    Quick, efficient, reliable service.

    12/28/2021

      Worked great, highly pure.

      05/12/2021

        Excellent for molecular experiments.

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