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Recombinant Human SERPINB1 Protein, His-tagged

Cat.No. : SERPINB1-778H
Product Overview : Recombinant Human SERPINB1 fused with His tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants.
Source : E. coli
Species : Human
Tag : His
Form : 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 100 mM Arg. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Molecular Mass : 42.7 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 [ Homo sapiens ]
Official Symbol : SERPINB1
Synonyms : SERPINB1; serpin peptidase inhibitor, clade B (ovalbumin), member 1; ELANH2, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1; leukocyte elastase inhibitor; anti elastase; EI; PI2; PI-2; serpin B1; anti-elastase; peptidase inhibitor 2; monocyte/neutrophil elastase inhibitor; protease inhibitor 2 (anti-elastase), monocyte/neutrophil derived; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 1; LEI; MNEI; M/NEI; ELANH2;
Gene ID : 1992
mRNA Refseq : NM_030666
Protein Refseq : NP_109591
MIM : 130135
UniProt ID : P30740

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does SERPINB1 contribute to the regulation of protease activity? 02/26/2021

It inhibits neutrophil elastase and cathepsin G, balancing proteolysis.

What are the molecular mechanisms regulating SERPINB1 expression and activity? 08/05/2020

Its expression and activity are regulated by various signaling pathways and transcription factors.

Are there therapeutic applications targeting SERPINB1? 07/01/2020

Potential therapeutic applications could involve modulating SERPINB1 to mitigate damage in inflammatory and infectious diseases.

What role does SERPINB1 play in inflammatory responses? 12/21/2019

It helps control inflammation by modulating protease activity in immune responses.

What is the main function of SERPINB1 in cellular processes? 12/17/2018

SERPINB1 functions as a serine protease inhibitor, regulating protease activity.

How is SERPINB1 implicated in diseases related to inflammation and infection? 07/27/2018

SERPINB1 protects tissues from damage during inflammation and infection.

In which cells or tissues is SERPINB1 predominantly expressed? 05/13/2018

SERPINB1 is predominantly expressed in neutrophils and some other immune cells.

Customer Reviews (3)

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Reviews
06/14/2022

    Quick, efficient, reliable service.

    12/28/2021

      Worked great, highly pure.

      05/12/2021

        Excellent for molecular experiments.

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