"TBCA" Related Products


Recombinant Tubulin Folding Cofactor A

Cat. No.: TBCA-4636H
Product Overview: TBCA Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids (1-108 a.a.) and having a molecular mass of 12.8 kDa. The TBCA is purified by proprietary chromatographic techniques.
Description: TBCA is a tubulin-folding protein which is involved in the early step of the tubulin folding pathway. TBCA is one of four proteins (cofactors A, D, E, and C) implicated in the pathway directing to properly folded beta-tubulin from folding intermediates. Cofactors A and D are thought to be a factor in capturing and stabilizing beta-tubulin in a quasi-native confirmation. TBCA is crucial for cell viability, if reduced it causes a decrease in the amount of soluble tubulin, alterations in microtubules and G1 cell cycle arrest. Cofactor E attaches to the cofactor D-tubulin complex, afterward, interaction with cofactor C triggers the release of tubulin polypeptides that are committed to the native state.
Source: Human
Host: Escherichia Coli.
Form: The TBCA solution contains 20mM Tris-HCl buffer pH 7.5, 1mM DTT and 10% glycerol.
Purity: Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Physical Appearance: Sterile Filtered colorless solution.
Storage: TBCA although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Pathways: Metabolism of proteins
Gene Name: TBCA tubulin folding cofactor A [ Homo sapiens ]
Official Symbol: TBCA
Synonyms: tubulin folding cofactor A; TBCA; tubulin-specific chaperone a; chaperonin cofactor A; CFA; TCP1-chaperonin cofactor A; Tubulin-folding cofactor A
Gene ID: 6902
mRNA Refseq: NM_004607
Protein Refseq: NP_004598
MIM: 610058
UniProt ID: O75347
Chromosome Location: 5q14.1
Function: chaperone binding; unfolded protein binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.