"TGM2" Related Products

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Recombinant Human Transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase), His-tagged

Cat. No.: TGM2-1481H
Product Overview: Tissue Transglutaminase Human Recombinant produced in E.coli is a non-glycosylated, polypeptide chain having a molecular mass of 78,018 Dalton. tTG is expressed with a -6xHis tag and purified by proprietary chromatographic techniques. By point mutation of the active center the catalytic transglutaminase activity has been eliminated, resulting in increased stability during storage and coating.
Description: Tissue-type transglutaminase antigens have been specifically modified for improved handling: exchange of an active site amino acid eliminates the protein cross-linking activity of the enzyme, while maintaining the native three-dimensional structure and the enzyme"s secondary GTPase activity. This engineering assures reproducible properties of the antigen preparations through the absence of variable and ill-defined covalent aggregates of tTG antigen and host cell proteins.
Source: Human
Host: Escherichia Coli.
Form: TGM2 is supplied in 16mM HEPES buffer pH-8.0, 400mM NaCl, and 20% glycerol.
Purity: Greater than 95.0% as determined by SDS-PAGE
Gene Name: TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) [ Homo sapiens ]
Official Symbol: TGM2
Synonyms: TGM2; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); TG2; TGC; GNAH; G-ALPHA-h; Protein-glutamine gamma-glutamyltransferase 2; TG(C); Tissue transglutaminase; TGase C; Transglutaminase-2; TGase-H; EC 2.3.2.13; OTTHUMP00000030960; C polypeptide; transglutaminase 2; transglutaminase C
Gene ID: 7052
mRNA Refseq: NM_004613
Protein Refseq: NP_004604
MIM: 190196
UniProt ID: P21980
Chromosome Location: 20q12
Pathway: Huntington"s disease
Function: GTP binding; acyltransferase activity; calcium ion binding; protein domain specific binding; protein-glutamine gamma-glutamyltransferase activity; transferase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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