Recombinant Human Sorbitol Dehydrogenase, His-tagged

• Cat.No.: SORD-2490H
• Product Overview: Recombinant human SORD protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 40.4 kDa (377aa).

Specification

• Cat. No.: SORD-2490H
• Description: SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid member of the zinc-containing alcohol dehydrogenase family. It is widely expressed with highest expression in kidney and in the lens of the eye. SORD enzymatically catalyzes the zinc-dependent interconversion of polyols, such as sorbitol and xylitol, to their respective ketoses.
• Source: E.coli.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAAAAKPNNL SLVVHGPGDL RLENYPIPEP GPN E VLLRMH SVGICGSDVH YWEYGRIGNF IVKKPMVLGH EASGTVEKVG SSVK HLKPGD RVAIEPGAPR ENDEFCKMGR YNLSPSIFFC ATPPDDGNLC RFYK HNAAFC YKLPDNVTFE EGALIEPLSV GIHACRRGGV TLGHKVLVCG AGPI GMVTLL VAKAMGAAQV VVTDLSATRL SKAKEIGADL VLQISKESPQ EIARKVEGQL GCKP EVTIEC TGAEASIQAG IYATRSGGTL VLVGLGSEMT TVPLLHAAIR EVDIK GVFRY CNTWPVAISM LASKSVNVKP LVTHRFPLEK ALEAFETFKK GLGLKIMLKC DPSDQNP.
• Storage: can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SORD sorbitol dehydrogenase [ Homo sapiens ]
• Synonyms: sorbitol dehydrogenase; SORD1; SORD; sorbitol dehydrogenase; L-iditol 2-dehydrogenase; EC 1.1.1.14
• Gene ID: 6652
• mRNA Refseq: NM_003104
• Protein Refseq: NP_003095
• MIM: 182500
• UniProt ID: Q00796
• Chromosome Location: 15q15.3
• Pathway: Fructose and mannose metabolism; Metabolic pathways
• Function: L-iditol 2-dehydrogenase activity; NAD or NADH binding; binding; metal ion binding; oxidoreductase activity; sugar binding; zinc ion binding