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Recombinant Human GUCA2A

Cat. No.: GUCA2A-3703H
Product Overview: Total 98 AA. MW: 11 kDa (calculated). 96 AA of the recombinant human Proguanylin and two N-Terminal extra AA (highlighted).
Description: GUCA2A is a 15 amino acid polypeptide that is secreted by goblet cells in the colon. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins.
Source: E. coli
Species: Human
Form: Filtered (0, 4 μm) and lyophilized in 0.5 mg/mL in deionized H2O.
Research topic: Energy metabolism and body weight regulation
Purity: >95%
Reconstitution: Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Applications: Western blotting
Quality Control Test: BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein
Sequences of amino acids: GPVTVQDGNF SFSLESVKKL KDLQEPQEPR VGKLRNFAPI PGEPVVPILC SNPNFPEELK PLCKEPNAQE ILQRLEEIAE DPGTCEICAY AACTGC
Storage: Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Gene Name: GUCA2A guanylate cyclase activator 2A (guanylin) [ Homo sapiens ]
Official Symbol: GUCA2A
Synonyms: GUCA2A; guanylate cyclase activator 2A (guanylin); GUCA2; STARA; GCAP-I; guanylin; OTTHUMP00000007926; guanylate cyclase-activating protein 1; guanylate cyclase-activating protein I; guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable)
Gene ID: 2980
mRNA Refseq: NM_033553
Protein Refseq: NP_291031
MIM: 139392
UniProt ID: Q02747
Chromosome Location: 1p35
Pathway: Myometrial Relaxation and Contraction Pathways
Function: guanylate cyclase activator activity; hormone activity

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