"KIAA1967" Related Products

Recombinant Human KIAA1967, His-tagged

Cat. No.: KIAA1967-3705H
Product Overview: Total 136AA. MW: 16kDa (calculated). N-Terminal His-tag 9AA (highlighted).
Description: KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene. Recent studies show that KIAA1967 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylateshistones and p53. KIAA1967 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.
Source: E. coli
Species: Human
Form: Filtered (0,4μm) and lyophilized in 0.5mg/mL in 0.05M MES bufferpH6.5
Researchtopic: Energy metabolism and body weight regulation
Purity: >95%
Reconstitution: Add deionized water to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. This product typically requires 20min at 37°C for complete reconstitution. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10μg/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Applications: Western blotting
QualityControl Test: BCA to determine quantity of the protein; SDS PAGE to determine purity of the protein
Sequences of aminoacids: MKHHHHHHHM IKKNLKKLGI EETYLNIIKA IYDRPTASIQ KTENLSTKTG TSQEYHLSPL WFYIVLEILA STIRQEKNLK DIHTEKEEVK LSLFADAMIL YLKKPNDSTR KLLELIKKIH SSCRIKINIH FAFCSQ
Storage: Store lyophilized protein at -20°C. Lyophilized protein remains stable until the expiry date when stored at -20°C. Aliquot reconstituted protein to avoid repeated freezing/thawing cycles and store at -80°C for long term storage. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at4°C.
Gene Name: KIAA1967 KIAA1967 [ Homo sapiens ]
Official Symbol: KIAA1967
Synonyms: KIAA1967; KIAA1967; DBC1; DBC-1; NET35; p30DBC; p30 DBC protein; DBC.1; OTTHUMP00000225106; OTTHUMP00000225109; deleted in breast cancer 1; deleted in breast cancer gene 1 protein
Gene ID: 57805
mRNA Refseq: NM_021174
Protein Refseq: NP_066997
MIM: 607359
UniProt ID: Q8N163
Chromosome Location: 8p22
Pathway: TNF-alpha/NF-kB Signaling Pathway
Function: enzyme binding; enzyme inhibitor activity; protein binding

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