Recombinant Human GRHPR, His-tagged GRHPR-2491H

Recombinant Human GRHPR, His-tagged

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Recombinant Human GRHPR, His-tagged

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Cat. No. : GRHPR-2491H
Product Overview : Recombinant human GRHPR protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 37.8 kDa (348aa).
Description : GRHPR, also known as GLXR, is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family of proteins. Localizing to the cytosol, GRHPR is ubiquitously expressed with highest expression levels found in liver. The protein has widespread tissue expression and has a role in metabolism. GRHPR is an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities.
Source : E.coli.
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 20% glycerol.
Purity : > 95% by SDS – PAGE.
Concentration : 0.5 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids : MGSSHHHHHH SSGLVPRGSH MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL.
Storage : can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
PDB rendering based on 2gcg. :

Gene Name : GRHPR glyoxylate reductase/hydroxypyruvate reductase [ Homo sapiens ]
Synonyms : glyoxylate reductase/hydroxypyruvate reductase; PH2; GLXR; GLYD; GRHPR; glyoxylate reductase/hydroxypyruvate reductase; glycerate-2-dehydrogenase; EC 1.1.1.79
Gene ID : 9380
mRNA Refseq : NM_012203
Protein Refseq : NP_036335
MIM : 604296
UniProt ID : Q9UBQ7
Chromosome Location : 9q12
Pathway : Glyoxylate and dicarboxylate metabolism; Metabolic pathways; Pyruvate metabolism
Function : NAD or NADH binding; cofactor binding; glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; hydroxypyruvate reductase activity; oxidoreductase activity; protein binding

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