Mouse Anti-Human MAT2A Monoclonal Antibody


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Mouse Anti-Human MAT2A Monoclonal Antibody

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Cat.No. : DMAB9748MH
Product Overview : Monoclonal Antibody to MAT2A.
Antigen Description : MAT2A is an important enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. MAT2A is expressed in extrahepatic tissues. In liver,MAT2A expression associates with growth,dedifferentiation,and cancer. NF-kappa B and AP-1 are necessary for basal MAT2A expression in HepG2 cells and mediate the increase in MAT2A expression in response to TNF-alpha. Up-regulation of MAT2A provides growth improvement and s-adenosylmethionine and methylthioadenosine thus can block mitogenic signaling in colon cancer cells. Lower expression of both MAT2A and MAT2beta and interfere with leptin signaling in liver cancer cells.
Target : MAT2A
Immunogen : Anti-human MAT2A mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human MAT2A amino acids 1-395 purified from E. coli.
Host : Mouse
Isotype : Mouse IgG2b heavy chain and κ light chain.
species : Human
Clone : QBU4B3BU
Purification : MAT2A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Applications : ELISA,WB,IHC
Concentration : 1mg/ml containing PBS,pH-7.4,& 0.1% Sodium Azide.
Storage : Stable for 1 year at -20 °C and 3 months at 4 °C. For maximum recovery of the product,centrifuge the original vial after thawing and before removing the cap. Aliquot to avoid repeated freezing and thawing.
Gene Name : MAT2A methionine adenosyltransferase II,alpha [ Homo sapiens ]
Official Symbol : MAT2A
Synonyms : MAT2A;methionine adenosyltransferase II,alpha;MATA2;MATII;SAMS2;S-adenosylmethionine synthase isoform type-2;MAT 2;MAT-II;adoMet synthase 2;adoMet synthetase 2;methionine adenosyltransferase 2;EC;AdoMet synthase 2;Methionine adenosyltransferase 2;
Gene ID : 4144
mRNA Refseq : NM_005911
Protein Refseq : NP_005902
MIM : 601468
UniProt ID : P31153
Chromosome Location : 2p11.2
Pathway : Biological oxidations;C-MYB transcription factor network;Cysteine and methionine metabolism;Metabolic pathways;Metabolism;Metabolism of amino acids and derivatives;Methionine degradation;
Function : ATP binding;metal ion binding;methionine adenosyltransferase activity;nucleotide binding;transferase activity

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