Mouse anti-CD10 Monoclonal Antibody

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Mouse anti-CD10 Monoclonal Antibody

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Cat. No. : CAB062
Antigen Information : Neprilysin, also known as neutral endopeptidase (NEP), CD10, and common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer"s disease. Synthesized as a membrane-bound protein, the neprilysin ectodomain is released into the extracellular domain after it has been transported from the Golgi apparatus to the cell surface. In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid beta.
concentration : 50µg/0.1ml 100µg/0.2ml
Application : IHC(P)1:100-500 IHC(F)1:100-500 ELISA 1:5000-10000
Storage : Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
The structure of the neprilysin ectodomain in complex with azinc-chelatinginhibitor. The zinc atom is shown as a gray sphere and the inhibitor is shown in green. Rendering based on 1r1h. Available structures:1dmt,1r1h,1r1i,1r1j,1y8j :

Gene Name : MME membrane metallo-endopeptidase [ Homo sapiens ]
Synonyms : membrane metallo-endopeptidase; DKFZp686O16152; MME; neutral endopeptidase; enkephalinase; neprilysin; Neutral endopeptidase 24.11; MME; CALLA; MGC126681; MGC126707; NEP;CD10; Enkephalinase; Atriopeptidase; Common acute lymphocytic leukemia antigen; membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
Gene ID : 4311
mRNA Refseq : NM_000902
Protein Refseq : NP_000893
MIM : 120520
UniProt ID : P08473
Chromosome Location : 3q25.1-q25.2
Pathway : Alzheimer"s disease;Hematopoietic cell lineage; Renin-angiotensin system
Function : metal ion binding; metalloendopeptidase activity; peptidase activity; protein binding; zinc ion binding

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