Recombinant Human Rho GDP Dissociation Inhibitor (GDI) Alpha


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Recombinant Human Rho GDP Dissociation Inhibitor (GDI) Alpha

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Cat. No. : ARHGDIA-4913H
Product Overview : Recombinant human ARHGDIA having a molecular mass of 54 kDa was expressed by E. coli.
Description : ARHGDIA belongs to the family of rho-GDI or GDP-dissociation inhibitors for the Rho/Rac family of small G proteins; consisting of rhoGDI-1, D4-GDI/rhoGDI-2 and rhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential for GTP-loading and activation of GTPase activity. ARHGDIA is located in the cytoplasm and is involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins. It is known to be a substrate for caspase 3 during Fas-mediated apoptosis.
Molecular Weight : 54 kDa
Source : E. coli
Species : Human
Form : 100μg/ml in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% Glycerol.
Appearance : Liquid
Endotoxin Level : <0.1 ng/μg
Purity : >90% as determined by SDS-PAGE and HPLC.
Storage : Stable at -20°C or -80°C. Stable for 6-12 months. Avoid freeze-thaw cycles.
Pathways : Axonal growth inhibition (RHOA activation); Axonal growth stimulation; CDC42 signaling events; Neurotrophin signaling pathway; RAC1 signaling pathway; Regulation of CDC42 activity; Regulation of RAC1 activity; Regulation of RhoA activity; Rho GTPase cycle; Signaling by Rho GTPases; Signalling by NGF; Vasopressin-regulated water reabsorption; p75 NTR receptor-mediated signalling; p75(NTR)-mediated signaling; p75NTR regulates axonogenesis
PDB rendering based on 1ajw. :

Gene Name : ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha [ Homo sapiens ]
Official Symbol : ARHGDIA
Synonyms : ARHGDIA; Rho GDP dissociation inhibitor (GDI) alpha; GDIA1; MGC117248; RHOGDI; RHOGDI-1; rho GDI 1; rho GDP-dissociation inhibitor 1; rho-GDI alpha
Gene ID : 396
mRNA Refseq : NM_004309
Protein Refseq : NP_004300
MIM : 601925
UniProt ID : P52565
Chromosome Location : 17q25.3
Function : GTPase activator activity; Rho GDP-dissociation inhibitor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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