Recombinant Human Rho GDP Dissociation Inhibitor (GDI) Alpha

• Cat.No.: ARHGDIA-4913H
• Product Overview: Recombinant human ARHGDIA having a molecular mass of 54 kDa was expressed by E. coli.

Specification

• Cat. No.: ARHGDIA-4913H
• Description: ARHGDIA belongs to the family of rho-GDI or GDP-dissociation inhibitors for the Rho/Rac family of small G proteins; consisting of rhoGDI-1, D4-GDI/rhoGDI-2 and rhoGDI-3. It inhibits the release of GDP from the Rho proteins, essential for GTP-loading and activation of GTPase activity. ARHGDIA is located in the cytoplasm and is involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins. It is known to be a substrate for caspase 3 during Fas-mediated apoptosis.
• Molecular Weight: 54 kDa
• Source: E. coli
• Species: Human
• Form: 100μg/ml in 50mM Tris-Acetate, pH 7.5, 1mM EDTA, 20% Glycerol.
• Appearance: Liquid
• Endotoxin Level: <0.1 ng/μg
• Purity: >90% as determined by SDS-PAGE and HPLC.
• Storage: Stable at -20°C or -80°C. Stable for 6-12 months. Avoid freeze-thaw cycles.
• Pathways: Axonal growth inhibition (RHOA activation); Axonal growth stimulation; CDC42 signaling events; Neurotrophin signaling pathway; RAC1 signaling pathway; Regulation of CDC42 activity; Regulation of RAC1 activity; Regulation of RhoA activity; Rho GTPase cycle; Signaling by Rho GTPases; Signalling by NGF; Vasopressin-regulated water reabsorption; p75 NTR receptor-mediated signalling; p75(NTR)-mediated signaling; p75NTR regulates axonogenesis

Gene Information

• Gene Name: ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha [ Homo sapiens ]
• Official Symbol: ARHGDIA
• Synonyms: ARHGDIA; Rho GDP dissociation inhibitor (GDI) alpha; GDIA1; MGC117248; RHOGDI; RHOGDI-1; rho GDI 1; rho GDP-dissociation inhibitor 1; rho-GDI alpha
• Gene ID: 396
• mRNA Refseq: NM_004309
• Protein Refseq: NP_004300
• MIM: 601925
• UniProt ID: P52565
• Chromosome Location: 17q25.3
• Function: GTPase activator activity; Rho GDP-dissociation inhibitor activity