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Recombinant Human Endoglin

Cat. No.: ENG-4917H
Product Overview: Recombinant human ENG was expressed in Sf9 insect cells and purified by proprietary chromatographic techniques.
Description: ENG is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex.The protein consists of a homodimer of 180 kDA with disulfide links. It has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. ENG has been found to be part of the TGF-beta1 receptor complex and may be involved in the binding of TGF-beta1, TGF-beta3, activin-A, BMP-2, and BMP-7. It has been postulated that endoglin is involved in the cytoskeletal organization affecting cell morphology and migration. ENG has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development.
Molecular Weight: 90.0 kDa
Source: Sf9 cells
Species: Human
Form: Lyophilized from PBS pH 7.4.
Appearance: Lyophilized protein
Reconstitution: Centrifuge the vial prior to opening. Reconstitute in sterile PBS to a concentration ≥100 µg/ml. This solution can then be diluted into other aqueous buffers.
Purity: ≥95% by SDS-PAGE and HPLC analyses
Storage: The lyophilized is best-stored desiccated at -20°C. Reconstituted human IL-1RA should be stored at 4°C for 2-7days and at -20°C for future use. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze/thaw cycles.
Pathways: HIF-1-alpha transcription factor network; TGF Beta Signaling Pathway; TGF-beta Receptor Signaling Pathway
Gene Name: ENG endoglin [ Homo sapiens ]
Official Symbol: ENG
Synonyms: ENG; endoglin; END; endoglin 1; CD105; CD105 antigen; CD_antigen=CD105; ORW; ORW1; FLJ41744; HHT1; Osler-Rendu-Weber syndrome 1; OTTHUMP00000022221
Gene ID: 2022
mRNA Refseq: NM_000118
Protein Refseq: NP_000109
MIM: 131195
UniProt ID: P17813
Chromosome Location: 9q33-q34.1
Function: activin binding; galactose binding; glycosaminoglycan binding; protein binding; contributes to protein binding; protein homodimerization activity; transforming growth factor beta receptor, cytoplasmic mediator activity; transmembrane receptor activity; type I transforming growth factor beta receptor binding; type II transforming growth factor beta receptor binding

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