Recombinant Human Aurora Kinase C, GST-tagged

• Cat.No.: AURKC-990H
• Product Overview: Recombinant full-length human AURKC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Cat. No.: AURKC-990H
• Description: AURKC is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. AURKC has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors. AURKC overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. AURKC is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 61 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
• Specific Activity: 65 nmol/min/mg
• Purity: > 80 %
• Concentration: 0.1 ug/ul
• Sequences: Full-length
• Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Aurora B signaling; Aurora C signaling; Signaling by Aurora kinases

Gene Information

• Gene Name: AURKC aurora kinase C [ Homo sapiens ]
• Official Symbol: AURKC
• Synonyms: AURKC; aurora kinase C; AIE2; AIK3; ARK3; AurC; STK13; aurora-C; serine/threonine-protein kinase 13; ARK-3; aurora-related kinase 3; aurora/IPL1/EG2 protein 2; aurora/IPL1-related kinase 3; serine/threonine-protein kinase aurora-C; serine/threonine kinase 13 (aurora/IPL1-like); Aurora-C
• Gene ID: 6795
• mRNA Refseq: NM_003160
• Protein Refseq: NP_003151
• MIM: 603495
• UniProt ID: Q5Y191
• Chromosome Location: 19q13.43
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity

Reviews

06/01/2020

It is very stable and can be stored and used for a long time.

12/02/2019

This price is very reasonable and good value for money.

03/18/2019

The activity is very strong and can meet my research needs.

Q&As

What is the role of AURKC protein in germ cell genesis?

AURKC protein plays an important role in germ cell genesis and is involved in the development, maturation and fertilization of sperm and egg.

What is the regulatory mechanism of AURKC protein activity?

The activity of AURKC protein is regulated by a variety of factors, including phosphorylation modification, protein interaction and cell cycle regulation.

At what stage of cell mitosis does AURKC protein reach its peak expression?

It reaches its peak expression during early and metaphase of cell mitosis and is closely associated with chromosome segregation and cell division.

How is AURKC protein associated with cancer?

The abnormal expression of AURKC protein in some cancers is associated with the initiation and progression of tumors. Further studies on the mechanism of action of AURKC protein in cancer may contribute to the development of cancer therapy.

What is the cellular localization of AURKC protein?

AURKC protein is mainly localized in the nucleus and cytoplasm and participates in the regulation of cell mitosis.

How is AURKC protein associated with reproductive disorders and infertility?

Mutation or abnormal expression of AURKC protein is associated with reproductive disorders and infertility in both males and females. Studies have found that AURKC gene mutations may lead to abnormal sperm or egg development and dysfunction.