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Recombinant Human BCL2-Associated X Protein, GST-tagged

Cat. No.: BAX-321H
Product Overview: Recombinant full-length human BAX was expressed in E. coli cells using an N-terminal GST tag.
Description: BAX is a proapoptotic protein of the BCL2 protein family. BAX forms a heterodimer with BCL2 and functions as an apoptotic activator. BAX interacts with and increases the opening of the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in the mitochondrial membrane potential and the release of cytochrome c. The expression of BAX gene is regulated by the tumor suppressor p53 and BAX has been shown to be involved in p53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Applications: Western Blot
Molecular Weight: 49 kDa
Expression System: E.coli
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol.
Purity: > 75 %
Concentration: 0.2 ug/ul
Sequences: Full-length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Activation; Amyotrophic lateral sclerosis (ALS); Apoptosis; B Cell Receptor Signaling Pathway; Caspase cascade in apoptosis; Ceramide signaling pathway; Colorectal cancer; Direct p53 effectors; HTLV-I infection; Huntington"s disease; IL-3 Signaling Pathway; Intrinsic Pathway for Apoptosis; Neurotrophin signaling pathway; Pathways in cancer; Protein processing in endoplasmic reticulum
Gene Name: BAX BCL2-associated X protein [ Homo sapiens ]
Official Symbol: BAX
Synonyms: BAX; BCL2-associated X protein; BCL2L4; apoptosis regulator BAX; bcl2-L-4; bcl-2-like protein 4; Bax epsilon; OTTHUMP00000218291; OTTHUMP00000218292; OTTHUMP00000218293; OTTHUMP00000218294; OTTHUMP00000218295; OTTHUMP00000218296
Gene ID: 581
mRNA Refseq: NM_004324
Protein Refseq: NP_004315
MIM: 600040
UniProt ID: O95074
Chromosome Location: 19q13.3-q13.4
Function: BH3 domain binding; channel activity; identical protein binding; lipid binding; protein binding; protein heterodimerization activity

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