Recombinant Human Cyclin-Dependent Kinase 1, GST-tagged
Cat.No. : | CDK1-998H |
Product Overview : | Recombinant full-length human CDK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | CDK1-998H |
Description : | CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated. |
Applications : | Kinase Assay; Western Blot |
Molecular Weight : | 58 kDa |
Expression System : | Sf9 insect cells using baculovirus |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol. |
Purity : | > 95 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | ARMS-mediated activation; Activated TLR4 signalling; Androgen Receptor Signaling Pathway; Axon guidance; Cell Cycle Checkpoints; Cell Cycle; Centrosome maturation; Cyclin B2 mediated events; Down-stream signal transduction; E2F transcription factor network; ERK activation; ERK1 activation; Gap junction; Hedgehog Signaling Pathway; Herpes simplex infection |
Gene Name : | CDK1 cyclin-dependent kinase 1 [ Homo sapiens ] |
Official Symbol : | CDK1 |
Synonyms : | CDK1; cyclin-dependent kinase 1; CDC2; CDC28A; P34CDC2; MGC111195; DKFZp686L20222; cell division cycle 2; OTTHUMP00000019659; OTTHUMP00000019660; OTTHUMP00000019661; p34 protein kinase; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; EC 2.7.11.23; EC 2.7.11.22; CCNA2; cyclin A2; CCN1; CCNA; Cyclin-A; Cyclin-A2 |
Gene ID : | 983 |
mRNA Refseq : | NM_001786 |
Protein Refseq : | NP_001777 |
MIM : | 116940 |
UniProt ID : | P06493 |
Chromosome Location : | 10q21.1 |
Function : | ATP binding; Hsp70 protein binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin binding; cyclin-dependent protein kinase activity; histone kinase activity; nucleotide binding; protein binding; protein kinase activity |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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