"CDK8" Related Products


Recombinant Human Cyclin-Dependent Kinase 8, GST-tagged

Cat. No. : CDK8-1003H
Product Overview : Recombinant full-length human CDK8 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description : CDK8 is a member of the CDK family which are important regulators of cell cycle progression. CDK8 associates with Cyclin C and is a component of the RNA polymerase II holoenzyme complex that phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. CDK8 regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH). Inhibition of CDK8 expression inhibits proliferation in colon cancer cells characterized by high levels of CDK8 and beta-catenin hyperactivity. CDK8 kinase activity is necessary for β-catenin-driven transformation and for expression of several β-catenin transcriptional targets.
Applications : Kinase Assay; Western Blot
Molecular Weight : 84 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25 % glycerol.
Purity : > 80 %
Concentration : 0.2 ug/ul
Sequences : Full-length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : Diabetes pathways; Gene Expression; Generic Transcription Pathway; Transcriptional Regulation of White Adipocyte Differentiation
Gene Name : CDK8 cyclin-dependent kinase 8 [ Homo sapiens ]
Official Symbol : CDK8
Synonyms : CDK8; cyclin-dependent kinase 8; K35; MGC126074; MGC126075; OTTHUMP00000018158; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; Cyclin-dependent kinase 8; EC; EC; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35
Gene ID : 1024
mRNA Refseq : NM_001260
Protein Refseq : NP_001251
MIM : 603184
UniProt ID : P49336
Chromosome Location : 13q12
Function : ATP binding; RNA polymerase II carboxy-terminal domain kinase activity; cyclin-dependent protein kinase activity; nucleotide binding; protein binding; protein kinase activity

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