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Recombinant Human Conserved Helix-Loop-Helix Ubiquitous Kinase, GST-tagged

Cat.No. : CHUK-1004H
Product Overview : Full length recombinant human CHUK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
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  • Gene Information
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Cat. No. : CHUK-1004H
Description : CHUK is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. CHUK is an essential regulator of NF-kappa-B-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure. CHUK is a critical component of the cytoplasmic transductional-transcriptional processor leading to induction of IFNα production. CHUK is also involved in the epidermis where it antagonizes mitogenic and angiogenic signals and represses tumor progression and metastases.
Applications : Kinase Assay; Western Blot
Molecular Weight : 114 kDa
Expression System : Sf9 insect cells using baculovirus
Species : Human
Form : Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 15 0mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM pmsf, 25 % glycerol.
Specific Activity : 2.5 nmol/min/mg
Purity : > 75 %
Concentration : 0.1 ug/ul
Sequences : Full length
Storage : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways : AKT phosphorylates targets in the cytosol; Activated TLR4 signalling; Acute myeloid leukemia; Adaptive Immunity Signaling; Adipocytokine signaling pathway; Alternative NF-kappaB pathway; Apoptosis; B Cell Receptor Signaling Pathway; BCR signaling pathway; Canonical NF-kappaB pathway; Chagas disease (American trypanosomiasis); Chemokine signaling pathway; Chronic myeloid leukemia; Class I PI3K signaling events mediated by Akt; Cytokine Signaling in Immune system
Gene Name : CHUK conserved helix-loop-helix ubiquitous kinase [ Homo sapiens ]
Official Symbol : CHUK
Synonyms : CHUK; conserved helix-loop-helix ubiquitous kinase; IKK1; IKKA; IKBKA; TCF16; NFKBIKA; IKK-alpha; Inhibitor of nuclear factor kappa-B kinase subunit alpha; inhibitor of nuclear factor kappa-B kinase subunit alpha; TCF-16; IKK-a kinase; I-kappa-B kinase 1; OTTHUMP00000020273; I-kappa-B kinase-alpha; transcription factor 16; IkB kinase alpha subunit; Nuclear factor NFkappaB inhibitor kinase alpha; I-kappa-B kinase alpha; IkappaB kinase; EC 2.7.11.10; Nuclear factor NF-kappa-B inhibitor kinase alpha
Gene ID : 1147
mRNA Refseq : NM_001278
Protein Refseq : NP_001269
MIM : 600664
UniProt ID : O15111
Chromosome Location : 10q24-q25
Function : ATP binding; IkappaB kinase activity; nucleotide binding; protein binding; protein kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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